抵抗素\超敏C反应蛋白及血脂水平与2型糖尿病并发心血管病变的相关性研究(1)
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摘要：目的 观察血清抵抗素、超敏C反应蛋白(hs-CRP)及血脂在2型糖尿病(T2DM)并发心血管病变患者中水平的变化及其相关关系。方法 选择单纯T2DM组50例，T2DM合并心血管病变组50例，分别测定血清抵抗素、hs-CRP及血脂等指标，以50名健康人作正常对照。结果 T2DM合并心血管病变组血清抵抗素和hs-CRP水平分别为(16.99±7.13) ng/mL、(4.97±2.88) mg/L，高于单纯T2DM组的(12.98±6.15) ng/mL、(3.61±1.49) mg/L，且均明显高于对照组的(9.32±4.46) ng/mL及(1.34±0.95)mg/L，3组两两比较差异有统计学意义(P<0.01)。T2DM组血脂水平除高密度脂蛋白胆固醇降低外，其余均比对照组明显升高(P<0.01)，而T2DM组之间比较无统计学意义(P>0.05)。T2DM合并心血管病变组血清抵抗素水平与hs-CRP呈正相关(r0.304，P<0.05)，而与血脂水平无相关性(P>0.05)。结论 血清抵抗素及hs-CRP可能作为炎症因子参与T2DM并发心血管病变发病机制，动态检测及时干预，可能有助于控制血管并发症的发生、发展。
关键词：抵抗素；超敏C反应蛋白；2型糖尿病；心血管病变
中图分类号：R587.1 R255.4 文献标识码：B 文章编号：1672-1349(2011)08-0930-03
Correlation between Resistin，hs-CRP，Lipid and Cardiovascular Disease in Type 2 Diabetes Mellitus
Zhong Guoquan，Yang Caixian，Zhou Xiuqin，et al
The Fifth Affiliated Hospital，Medical School，Jinan University (Qingyuan 511500)
Abstract:Objective To explore the relationship between ressistin，high-sensitivity C reactive protein (hs-CRP)，lipid and cardiovascular disease in type 2 diabetes mellitus (T2DM).Methods Fifty patients (pts) with T2DM and 50 T2DM pts with cardiovascular disease were selected.Fifty healthy individuals were as the controls.The levels of serum ressistin，hs-CRP，and lipid were measured.Results The levels of resistin and hs-CRP in T2DM pts with cardiovascular disease were 16.99 ng/mL±7.13 ng/mL and 4.97 mg/L±2.88 mg/L ......
摘要：目的 观察血清抵抗素、超敏C反应蛋白(hs-CRP)及血脂在2型糖尿病(T2DM)并发心血管病变患者中水平的变化及其相关关系。方法 选择单纯T2DM组50例，T2DM合并心血管病变组50例，分别测定血清抵抗素、hs-CRP及血脂等指标，以50名健康人作正常对照。结果 T2DM合并心血管病变组血清抵抗素和hs-CRP水平分别为(16.99±7.13) ng/mL、(4.97±2.88) mg/L，高于单纯T2DM组的(12.98±6.15) ng/mL、(3.61±1.49) mg/L，且均明显高于对照组的(9.32±4.46) ng/mL及(1.34±0.95)mg/L，3组两两比较差异有统计学意义(P<0.01)。T2DM组血脂水平除高密度脂蛋白胆固醇降低外，其余均比对照组明显升高(P<0.01)，而T2DM组之间比较无统计学意义(P>0.05)。T2DM合并心血管病变组血清抵抗素水平与hs-CRP呈正相关(r0.304，P<0.05)，而与血脂水平无相关性(P>0.05)。结论 血清抵抗素及hs-CRP可能作为炎症因子参与T2DM并发心血管病变发病机制，动态检测及时干预，可能有助于控制血管并发症的发生、发展。
关键词：抵抗素；超敏C反应蛋白；2型糖尿病；心血管病变
中图分类号：R587.1 R255.4 文献标识码：B 文章编号：1672-1349(2011)08-0930-03
Correlation between Resistin，hs-CRP，Lipid and Cardiovascular Disease in Type 2 Diabetes Mellitus
Zhong Guoquan，Yang Caixian，Zhou Xiuqin，et al
The Fifth Affiliated Hospital，Medical School，Jinan University (Qingyuan 511500)
Abstract:Objective To explore the relationship between ressistin，high-sensitivity C reactive protein (hs-CRP)，lipid and cardiovascular disease in type 2 diabetes mellitus (T2DM).Methods Fifty patients (pts) with T2DM and 50 T2DM pts with cardiovascular disease were selected.Fifty healthy individuals were as the controls.The levels of serum ressistin，hs-CRP，and lipid were measured.Results The levels of resistin and hs-CRP in T2DM pts with cardiovascular disease were 16.99 ng/mL±7.13 ng/mL and 4.97 mg/L±2.88 mg/L ......
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