麝香保心丸联合美托洛尔治疗冠状动脉心肌桥疗效观察(1)
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摘要:目的 探讨麝香保心丸联合美托洛尔(倍他乐克)治疗冠状动脉心肌桥的临床疗效和可行性。方法 选择冠脉心肌桥患者72例,随机分为治疗组和对照组。两组患者都服用抗血小板聚集药(阿司匹林100 mg,口服,每日1次)、β受体阻滞药(倍他乐克12.5 mg,口服,每日两次)治疗。治疗组在此基础上加用麝香保心丸(2粒,口服,每日3次)。治疗期间观察两组患者每周心绞痛症状发作次数及症状改善情况。结果 治疗组与对照组相比,胸闷、气短、心慌症状改善,能有效缓解胸痛症状。治疗组总有效率91.67%,与对照组63.89%比较有统计学意义。结论 麝香保心丸联合倍他乐克治疗心肌桥可以减轻心肌桥压迫,从而缓解心绞痛发作次数,明显改善患者临床症状。
关键词:麝香保心丸;美托洛尔;心肌桥;320排动态容积CT
中图分类号:R541.4 R289.5 文献标识码:B 文章编号:1672-1349(2012)01-0003-02
Clinical Observation of Shexiang Baoxin Pill and Metoprolol for Treatment of Coronary Myocardial Bridge
Fan Guanghui,He Yaxiong,Zou Jiani,et al // Wuhan General Hospital,Guangzhou Military Command (Wuhan 430070)
Abstract:Objective To investigate the clinical efficacy and feasibility of Shexiang Baoxin pill and metoprolol for patients with coronary myocardial bridge.Methods Seventy-two patients (pts) with coronary myocardial bridge were randomly divided into two groups:Control group treated by aspirin and metoprolol and treatment group treated by Shexiang Baoxin pill,aspirin and metoprolol.Angina episodes and the improvements of symptoms were observed.Results Compared with the control group,the symptoms of chest tightness,shortness of breath,palpitation were relieved effectively in treatment group.The total clinical effective rate was 91.67% in treatment group,which was higher than that in control group(63.89%,P<0.05).Conclusion Shexiang Baoxin pill with metoprolol could reduce the myocardial bridge oppression,decrease the number of attacks,significantly improve the clinical symptoms in pts with myocardial bridge.
Key words:Shexiang Baoxin pill;metoprolol;myocardial bridge;dynamic volume CT
冠状动脉心肌桥(MB)是指冠状动脉主干及其分支走行于心外膜下的脂肪组织中或者心外膜下,如果一段冠状动脉行走于心肌纤维中,在心肌内行走,被心肌覆盖的冠状动脉段称为壁冠状动脉(mural coronary artery),覆盖在冠状动脉上的心肌称为心肌桥(myocardial bridge)。壁冠状动脉内的血流量会受到覆盖其上的心肌纤维的影响。心脏处于收缩期时,壁冠状动脉受心肌的挤压,导致短暂的间歇性狭窄;而心脏处于舒张期时,壁冠状动脉恢复正常。冠状动脉心肌桥可致心绞痛甚至心肌梗死[1]。本研究主要探讨麝香保心丸联合美托洛尔(倍他乐克)治疗心肌桥的疗效。
1 资料与方法
1.1 临床资料 选择2011年1月—2011年9月以胸闷和胸痛为主诉,在我院心内科门诊的患者,行平板运动实验或者动态心电图检查可疑阳性(心电图ST-T改变),经门诊行320排冠状动脉血管成像(CTA)检查,检测出72例患者有冠状动脉心肌桥,男56例,女16例,共72例心肌桥,年龄35岁~64岁(48.6岁±6.7岁)。随机分为治疗组和对照组。两组主要临床症状、胸痛发作次数及一般情况(年龄、性别、危险因素)无统计学意义(P>0.05)。详见表1。
1.2 操作方法 扫描设备使用日本东芝Aquilion ONE 320排CT机 ......
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