高尿酸血症与冠心病及危险因素的相关性分析(1)
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摘要:目的 通过对高尿酸血症与冠心病及危险因素的横断面研究，分析高尿酸血症与冠心病及危险因素的相关性。方法 入选太原市中心医院心内科符合标准患者150例，依据尿酸水平分为高尿酸血症组(80例)及非高尿酸血症组(70例)。记录年龄、性别、身高、体重、腰围、臀围、血压及血生化指标等基本资料，通过横断面研究高尿酸血症与冠心病及危险因素的关系。结果 高尿酸血症组与非高尿酸血症组比较，在吸烟年限、收缩压(SBP)、舒张压(DBP)、腰围、腰臀比、体重指数(BMI)、三酰甘油、总胆固醇、空腹血糖等均有统计学意义(P<0.05)。高尿酸与冠心病间存在相关性。针对高尿酸血症危险因素空腹血糖(FBG)、低密度脂蛋白胆固醇(LDL-C)、BMI以及代谢综合征(MS)四者进行多元Logistic回归分析，并校正年龄、性别、吸烟、饮酒后分析表明，MS(校正前OR=1.110，校正后OR=1.111，P<0.001)及FBG(校正前OR=2.586，校正后OR=2.685，P<0.001)是高尿酸血症的独立危险因素，而LDL-C(校正前OR=0.638，校正后OR=0.642，P<0.05)则是高尿酸血症的保护因素。BMI的Logistic回归分析无统计学意义(校正前OR=0.795，校正后OR=0.757)。结论 高尿酸血症与冠心病存在一定的协同作用；在高尿酸血症的危险因素中MS、FBG是高尿酸血症的独立危险因素，LDL-C是高尿酸血症的保护因素。
关键词：高尿酸血症；冠心病；危险因素；代谢综合征
中图分类号：R541.4 R256.2 文献标识码：B 文章编号：1672-1349(2012)01-0009-03
Relationship between Hyperuricemia,Coronary Heart Disease and Its Risk Factors
Wang Yanbin,Qiu Fubin,Ren SufangDepartment of Cardiology,Taiyuan Central Hospital,Shanxi Medical University (Taiyuan 030009)
Abstract:Objective To analyze the relationship between hyperuricemia,coronary heart disease and its risk factors.Methods One hundreds and fifty patients (pts) were divided into high uric acid group (n=80) and non-high uric acid group (n=70).The age,sex,height,weight,waist circumference(WC),hip circumference(BP),blood pressure,blood glucose,creatinine,uric acid,total cholesterol(TC),triglyceride(TG),low density lipoprotein-cholesterol(LDL-C) and high density lipoprotein-cholesterol (HDL-C) and other basic information were recorded and analyzed by cross-sectional study.Results There were significantly difference in years of smoking, systolic BP (SBP), diastolic BP (DBP),WC, waist to hip (WHR),body mass index (BMI),TG,TC,fasting blood glucose(FBG),and creatinine in two groups (P<0.05).Adjusting for age,sex,smoking,and alcohol consumption,FBG,LDL-C,BMI and metabolic syndrome (MS) were analyzed by multivariate logistic regression analysis and showed MS[odds ratio (OR)=1.110,adjusted OR=1.111,P<0.001],FBG (OR=2.586,adjusted OR=2.685,P<0.001),and higher serum uric acid were independent risk factor.LDL-C (OR=0.638,adjusted OR=0.642,P<0.05) was a protective factor for hyperuricemia.There was no relation between hyperuricemia and BMI (OR=0 ......
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