心衰合剂对慢性心力衰竭患者N末端脑利钠肽前体的影响(1)
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摘要：目的 观察心衰合剂对慢性心力衰竭(心衰)患者N末端脑利钠肽前体(NTproBNP)的影响。方法 选取2009年1月—2009年12月在北京中医药大学东方医院心内科住院的心衰患者60例，按Framingham诊断标准进行评估，随机分为两组，各30例。治疗组在西医标准治疗心衰基础上加用心衰合剂；对照组仅用西医对心衰的标准治疗。治疗15 d后重新评价心功能分级、射血分数(EF)以及NTproBNP浓度。结果 治疗后，治疗组NTproBNP浓度较对照组有明显下降，差异有统计学意义(P<0.05)，而心功能分级、EF值差异无统计学意义。结论 NTproBNP较EF和心功能分级敏感性更高，是一个很好的评价中药治疗慢性心衰疗效的指标。
关键词：心衰合剂；心衰；N末端脑利钠肽前体；射血分数；心功能分级
中图分类号：R541.6 R289.5 文献标识码：B 文章编号：16721349(2012)08090202
Effects of Xinshuai Mixture on Nterminal proBNP in Chronic Heart Failure
Li Hui，Tang Daxuan，Guo WeiqinDepartment of Cardiology，Dongfang Hospital，Beijing University of Traditional Chinese Medicine (Beijing 100078)
Abstract：Objective To investigate the effects of Xinshuai mixture on heart failure ejection fraction (EF) and Nterminal probrain natriuretic peptide (NTproBNP) in patients with choric heart failure.Methods Sixty inpatients with heart failure were selected and divided into treatment group (n＝30) received Xinshuai mixture and standard western medicine therapy and control group (n＝30) receive standard western medicine therapy alone for 15 days.Heart function classification，EF and NTpro BNP levels were reevaluated.Results At the end of treatment，comparing with the control group，NTproBNP levels in treatment group was declined，and the differences were statistically significance.There were no statistically differences in New York Heart Association (NYHA) classifications and EF.Conclusion NTproBNP was more sensitive than EF and NYHA，and it might be a good index to evaluate traditional Chinese drugs for treatment of chronic heart failure.
Key words:Xinshuai mixture；heart failure；Nterminal probrain natriuretic peptide；ejection fraction
心力衰竭(心衰)是重大公共卫生问题。由于人口老龄化和对其他主要心血管病治疗效果的改善,使冠心病、高血压以及其他患者生存时间延长,心衰的发病率呈升高趋势。心衰患者数量的增加也带来了严重的社会负担，美国每年用于心力衰竭患者的医疗费用高达279亿美元[1]。现代医学尽管对心衰的发病机制有了进一步认识 ......
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