摘要：Toll受体4(TLR4)能识别多种病原相关分子模式,并能促进白细胞浸润、脂质核心的形成、纤维帽变薄、血管新生等病理过程，在动脉粥样硬化易损斑块的发生发展中的作用极其重要。TLR4能激活核转录因子(NFκB)和促炎性蛋白，进一步促进炎症反应的发生和动脉粥样斑块的不稳定性增加。本文总结近年有关动脉粥样硬化易损斑块与TLR4/NFκB信号通路关系的研究进展。

    关键词：动脉粥样硬化；Toll受体4; 核转录因子；易损斑块

    中图分类号：R543.5R256.2文献标识码：Adoi:10.3969/j.issn.16721349.2014.06.054文章编号：16721349(2014)06074703

    Toll Receptor 4/NFkB Signaling Pathway in Atherosclerotic Vulnerable Plaque

    Yang Jun,Yue Zenghui,Xie Tao,et al

    Hunan University of Traditional Chinese Medicine (Changsha 410000)

    Abstract：Toll receptor 4(TLR4) can identify PAMPs,and promote leukocyte infiltration,the formation of lipid core,the thinning of the fibrous cap and angiogenesis and so on.It has a extremely important role in the development of atherosclerosis vulnerable plaque.TLR4 can activatenuclear factor kappa B (NFκB)transcription factors and proinflammatory protein,then promote the inflammatory reaction and increase the instability of atherosclerotic plaque inflammation.This review will discuss advances of the relationship between TLR4/NFκB signaling pathway and atherosclerotic vulnerableplaque from three aspects. ......