Effect of Sacubactril Valsartan Combined with Astragalus Angelica Mixture on Renal Function and Serum HMGB1 and IL-6 Levels in Patients with Primary Hypertension and Early Renal Injury

    LI Yong， SU Yakun， ZHANG Hongbo， YAN Xiaoju， LI Zhanhu

    Hengshui People′s Hospital， Hengshui 053000， Hebei， China

    Corresponding Author "LI Yong， E-mail： hsliyong2008@163.com

    Keywords ""hepertensive renal injury; sacubactril valsartan; Astragalus Angelica Mixture; high-mobility group box-1 protein; interleukin-6

    摘要""目的：探讨沙库巴曲缬沙坦联合黄芪当归合剂对原发性高血压早期肾损伤病人肾功能及血清高迁移率蛋白B1(HMGB1)、白细胞介素-6(IL-6)水平的影响。方法：入选130例原发性高血压早期肾损伤病人，随机分为观察组(67例)"和对照组(63例)。对照组给予沙库巴曲缬沙坦治疗，观察组在对照组治疗基础上加用黄芪当归合剂，连续治疗3个月。观察两组病人治疗前后收缩压(SBP)、舒张压(DBP)及中医证候积分的变化 ......