【中图分类号】R 737 【文献标识码】A 【文章编号】1672-3783(2011)07-0275-01

    【摘要】目的 分析宫颈癌患者的HPV-E7检测的临床意义。方法 收集120例治疗前病例的颈管泌物，用第二代杂交捕获技术(HC-Ⅱ)对β种高危型 HPV-E7和5种低危型HPV-E7进行定性检测。结果 HPV-E7阳性者101例，阳性率84.17%，在≤40岁、40~50岁、≥50岁3个年龄段，HPV-E7阳性率分别为94.7%，82.5%，64.2%(P<0.05)。宫颈鳞癌的HPV-E7阳性率95.2%，明显高于腺癌35%、腺鳞癌25%(P<0.01)。结论 HPV感染是宫颈癌的重要致病因素；HPV- E7可作为宫颈癌前病变和HPV-E7活化状态的生物标志物。鳞癌的发生与 HPV-E7感染的关系较腺癌更密切。

    【关键词】宫颈癌HPV感染杂交捕获二代系统 HPV感染

    【Abstract】Objective analysis of cervical cancer patients HPV - E7 detection clinical significance. Methods collecting 120 patients before treatment GuanBi content, the neck cases with the second generation hybrid capture technology (HC - Ⅱ) to beta kind of high-risk type HPV - and 5 E7 low-risk type HPV - E7 for qualitative detection. Results HPV - E7 positive rate of 101 cases, 84.17%, more than 40 years old, in 40 ~ 50 year old, P, three age 50 years old respectively HPV - E7 positie, 94.7% -makers, 64.2 (P < 0.05). Cervical squamous cell carcinoma of the HPV - E7 diseases was 95.2%; significantly higher rate of 35%, adenocarcinoma glandular squamous cell carcinomas 25% (P < 0.01). Conclusion HPV infection is an important pathogenic factors; cerical cancer HPV - E7 lesion before as cervical cancer HPV - E7 activation state of biological markers. The occurrence of squamous cell carcinoma with HPV - E7 infection relations more adenocarcinoma more closely. ......