【摘 要】 ：目的 对比观察莫西沙星和左氧氟沙星治疗耐多药肺结核患者的临床疗效。方法 收集某院2016年 6月—2019年6月300例耐多药肺结核患者依据治疗方式不同分为莫西沙星组和左氧氟沙星组，对比治疗效果并分析。结果 莫西沙星组的痰菌转阴率(84.67%)病灶吸收率(86.00%)和空洞改善率(68.00%)均高于左氧氟沙星组，差异均有统计学意义(Х2=5.285，P<0.05;Х2=4.573，P<0.05;Х2=12.1154，P<0.05);而莫西沙星組不良反应发生率与左氧氟沙星组比较，差异无统计学意义(P>0.05)。结论 莫西沙星联合基本抗结核药对耐多药肺结核的治疗效果和左氧氟沙星相比，莫西沙星的治疗效果较好，痰菌转阴率和空洞改善率提高，且安全性与左氧氟沙星接近。故此，值得临床推广应用。

    【关键词】：耐多药肺结核;莫西沙星;痰菌转阴率;病灶吸收;空洞闭合

    ABSTRACT： OBJECTIVE To compare the clinical efficacy of moxifloxacin and levofloxacin in the treatment of multi-drug resistant pulmonary tuberculosis Patients.METHODS A retrospective collection of 300 patients with multidrug-resistant tuberculosis resistance from June 2018 to June 2019 in a hospital was conducted to analyze their drug resistance and treatment effect.RESULTS Moxifloxacin group of sputum bacteria turn rate (84.67%) lesion absorption rate(86.00%) and empty period (68.00%) were higher than in levofloxacin group ......