应用ROC曲线确定肾病综合征D-二聚体定量诊断临界值及意义
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[摘 要] 目的：应用ROC曲线确定肾病综合征D-二聚体定量诊断临界值及意义。方法：依据肾病综合征诊断标准收集我院行D-二聚体定量检查患者标本81例，采用免疫比浊法检测D-二聚体含量并绘制ROC曲线，应用统计软件进行分析，确定诊断临界值。结果：D-二聚体用于肾病综合征的诊断临界值为1.2μg/ml(敏感度为86.42%，特异性为54.55%)。结论：本次研究确定肾病综合征D-二聚体诊断临界值，相对于试剂盒推荐诊断临界值(0.5μg/ml)具有更好的准确性，能够有效提高临床诊断效率，具有临床推广使用价值。
[关键词] ROC；D-二聚体；肾病综合征
[Abstract Objective] To determine the diagnosis cut-off point of nephrotic syndrome by D-dimer content using ROC curve and appraise its clinical significance Method The patients’ specimens were collected According to nephrotic syndrome diagnosis standard, using immunoturbidimetric methods to measure the D- dimer content, draw up the ROC curve, and determine the diagnosis cut-off point of nephrotic syndrome by statistical analysis. Result the D-dimer cut-off point of nephrotic syndrome clinical diagnosis is 1.2μg/ml (sensitivity is 86.42%, specificity is 54.55%) Conclusion The cut-off point determined by this research compared to 0.5μg/ml provided by the reagent box as the same diagnosis standards possess better accuracy, effectively improve the efficiency of clinical diagnosis and is worthy to be used in clinical areas ......
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