来氟米特联合糖皮质激素治疗狼疮性肾炎的临床疗效
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【摘要】:目的:观察新型免疫抑制剂来氟米特联合糖皮质激素治疗狼疮性肾炎的临床疗效。方法:对23例狼疮性肾炎患者,观察来氟米特1mg/kg·d连续口服3天后,改为20mg/d维持口服,并常规应用糖皮质激素1mg/kg·d(不超过60mg),2月后逐渐减量至10-15mg/d,未用其他免疫抑制剂,其治疗前后临床和免疫指标,不良反应。结果:狼疮性肾炎患者使用来氟米特联合糖皮质激素6月,24小时尿蛋白定量由5.3±2.6g,降为2.3±1.9g(P<0.001)。结论:来氟米特能较好控制狼疮性肾病的病情活动,防止复发,副作用小,是目前较理想的一种治疗流行狼疮性肾炎的新型免疫抑制剂。
关键词:狼疮性肾炎;来氟米特;治疗Abstract: Objective:Observes the new immunity inhibitor to come fluorine Mitter to unite the sugar cortical hormone treatment lupous nephritis’s clinical curative effect. Methods: To 23 example lupous nephritis patient, observes fluorine Mitter 1mg/kg·d takes orally 3 days later continuously, changes the 20mg/d maintenance oral administration, and the convention (does not surpass 60mg) using sugar cortical hormone 1mg/kg·d, after in February, the decrement to 10-15mg/d, has not used other immunity inhibitor gradually, around its treatment clinical and immunity target, untoward effect ......
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