富马酸替诺福韦二吡呋酯片对慢性乙型肝炎的治疗效果(1)
【摘 要】目的：探讨富马酸替诺福韦二吡呋酯片对慢性乙型肝炎的疗效。方法：随机选取30例慢性乙型肝炎患者，采用富马酸替诺福韦二吡呋酯片治疗，疗程4周;在治疗前后检测患者的肝功能和乙型肝炎病毒脱氧核糖核酸(HBV-DNA)，根据这些指标的变化评价疗效。结果：与治疗前比较，治疗后丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)和γ-谷氨酰转肽酶(GGT)这 3种肝酶水平明显下降(P<0.05)，HBV-DNA阳性率显著下降(P<0.01)。结论：富马酸替诺福韦二吡呋酯片对慢性乙型肝炎的疗效显著，不但能改善肝功能，更能有效地抑制病毒复制。
【关键词】富马酸替诺福韦二吡呋酯片;慢性乙型肝炎;肝功能;乙型肝炎病毒
【中图分类号】R512 【文献标识码】A 【文章编号】1672-3783(2020)03-0117-01
, 百拇医药
Therapeutic effect of Tenofovir Dipivoxil Fumarate Tablets for Chronic Hepatitis B
Lian Yongguang， Li Jun， Yuan Guomei， Chen Shecai
(Xinhui Traditional Chinese Medicine Hospital，Jiangmen，Guangdong 529100 China)
【Abstract】Objective： To probe into the therapeutic effects of tenofovir dipivoxil fumarate tablets for the chronic hepatitis B.Methods： The 30 patients of chronic hepatitis B were randomly selected and were treated to use the tenofovir dipivoxil fumarate tablets. The course of treatment was four weeks. The liver function and DNA of hepatitis B virus (HBV-DNA) for the patients were detected before and after treatment and the therapeutic effects were evaluated according to the variation of these indexes.Results：The liver enzymes levels such as the alanine aminotransferase (ALT)， aspartate aminotransferase (AST) and γ-glutamyl transpeptidase (GGT) obviously reduced (P<0.05) and the positive rate of HBV-DNA apparently reduced (P<0.01) after treatment in contrast with before treatment. Conclusions： The therapeutic effects of tenofovir dipivoxil fumarate tablets for the chronic hepatitis B are apparent and this therapy not only can improve the liver function but also can effectively restrain the reproduction of virus.
, 百拇医药
【Key words】Tenofovir dipivoxil fumarate tablets; Chronic hepatitis B; Liver function; Hepatitis B virus
慢性乙型肝炎是由于感染乙型肝炎病毒(HBV)引起的，乙型肝炎患者和HBV攜带者是本病的主要传染源，HBV可通过母婴、血和血液制品、破损的皮肤黏膜及性接触传播。感染HBV后，由于受病毒因素、宿主因素、环境因素等影响，会出现不同的结局和临床类型。据世界卫生组织报道，全球约20亿曾感染过HBV，其中3.5亿为慢性HBV感染者，应用核苷类似物等抗病毒治疗是慢性乙型病毒肝炎的根本治疗方法[1]。本文随机选取2018年1月至2019年5月我院门诊的慢性乙型病毒肝炎患者，采用富马酸替诺福韦二吡呋酯片(简称“替诺福韦”)进行治疗，取得较好疗效，现报道如下。
1 对象与方法
1.1 临床病例
随机选取门诊的慢性乙型肝炎患者30例，诊断均符合2010年中华医学会肝病分学会和感染病学会制订的《慢性乙型肝炎防治指南》[1]。排除合并其他肝炎病毒感染、自身免疫性肝病、肝硬化和肝细胞癌等肝脏疾病患者。其中男18例，女12例;年龄23～53岁(平均40.6±8.7岁)。, http://www.100md.com(梁永广 李俊 阮国梅 陈社财)
【关键词】富马酸替诺福韦二吡呋酯片;慢性乙型肝炎;肝功能;乙型肝炎病毒
【中图分类号】R512 【文献标识码】A 【文章编号】1672-3783(2020)03-0117-01
, 百拇医药
Therapeutic effect of Tenofovir Dipivoxil Fumarate Tablets for Chronic Hepatitis B
Lian Yongguang， Li Jun， Yuan Guomei， Chen Shecai
(Xinhui Traditional Chinese Medicine Hospital，Jiangmen，Guangdong 529100 China)
【Abstract】Objective： To probe into the therapeutic effects of tenofovir dipivoxil fumarate tablets for the chronic hepatitis B.Methods： The 30 patients of chronic hepatitis B were randomly selected and were treated to use the tenofovir dipivoxil fumarate tablets. The course of treatment was four weeks. The liver function and DNA of hepatitis B virus (HBV-DNA) for the patients were detected before and after treatment and the therapeutic effects were evaluated according to the variation of these indexes.Results：The liver enzymes levels such as the alanine aminotransferase (ALT)， aspartate aminotransferase (AST) and γ-glutamyl transpeptidase (GGT) obviously reduced (P<0.05) and the positive rate of HBV-DNA apparently reduced (P<0.01) after treatment in contrast with before treatment. Conclusions： The therapeutic effects of tenofovir dipivoxil fumarate tablets for the chronic hepatitis B are apparent and this therapy not only can improve the liver function but also can effectively restrain the reproduction of virus.
, 百拇医药
【Key words】Tenofovir dipivoxil fumarate tablets; Chronic hepatitis B; Liver function; Hepatitis B virus
慢性乙型肝炎是由于感染乙型肝炎病毒(HBV)引起的，乙型肝炎患者和HBV攜带者是本病的主要传染源，HBV可通过母婴、血和血液制品、破损的皮肤黏膜及性接触传播。感染HBV后，由于受病毒因素、宿主因素、环境因素等影响，会出现不同的结局和临床类型。据世界卫生组织报道，全球约20亿曾感染过HBV，其中3.5亿为慢性HBV感染者，应用核苷类似物等抗病毒治疗是慢性乙型病毒肝炎的根本治疗方法[1]。本文随机选取2018年1月至2019年5月我院门诊的慢性乙型病毒肝炎患者，采用富马酸替诺福韦二吡呋酯片(简称“替诺福韦”)进行治疗，取得较好疗效，现报道如下。
1 对象与方法
1.1 临床病例
随机选取门诊的慢性乙型肝炎患者30例，诊断均符合2010年中华医学会肝病分学会和感染病学会制订的《慢性乙型肝炎防治指南》[1]。排除合并其他肝炎病毒感染、自身免疫性肝病、肝硬化和肝细胞癌等肝脏疾病患者。其中男18例，女12例;年龄23～53岁(平均40.6±8.7岁)。, http://www.100md.com(梁永广 李俊 阮国梅 陈社财)