综合疗法干预微量白蛋白对社区治疗糖尿病肾病的效果分析(1)
[摘要] 目的 研究社区综合疗法干预糖尿病肾病病人微量白蛋白的效果分析。 方法 选取该院于2010年10月—2015年10月收治的315例2 型糖尿病患者作为研究对象，随机分为干预组和对照组，干预组给予综合疗法，对照组给予常规治疗，疗程结束后检测患者血糖、尿微量白蛋白和肾功能情况。结果 治疗前，对照组与干预组患者空腹血糖、餐后2 h血糖及糖化血红蛋白比较差异均无统计学意义(P>0.05)。治疗后，干预组患者空腹血糖降至(5.61±0.45)mmol/L;对照组患者空腹血糖降至(6.34±0.72)mmol/L，两组治疗前、后相比，差异均有统计学意义(P<0.05);干预组患者餐后2 h血糖(6.61±0.66)mmol/L、糖化血红蛋白(6.12±0.77)%均低于对照组，差异有统计学意义(P<0.05)，两组治疗前、后相比，差异均有统计学意义(P<0.05);治疗前，对照组与干预组患者尿微量蛋白、血肌酐、血尿素氮、内生肌酐清率和同型半胱氨酸比较差异均无统计学意义(P>0.05)。治疗后，对照组患者尿微量蛋白、血肌酐、血尿素氮、内生肌酐清率和同型半胱氨酸与治疗前相比，差异均无统计学意义(P>0.05);干预组患者尿微量蛋白降至(18.9±7.2)mg、血肌酐降至(70±12)μmol/L、血尿素氮降至(6.8±1.4)mmol/L、内生肌酐清率降至(106±13)mL/min、同型半胱氨酸降至(13.98±6.7)mmol/L与治疗前相比，差异均有统计学意义(P<0.05)，与对照组治疗后相比，差异均有统计学意义(P<0.05)。 结论 综合疗法，能够控制病人血糖，减轻患者肾脏损害，延缓糖尿病肾病的进程，可以在社区医院中推广应用
[关键词] 综合疗法;糖尿病肾病;微量白蛋白
[中图分类号] R473.2 [文献标识码] A [文章编号] 1672-4062(2016)01(a)-0110-04
Combination Therapy Intervention Albumin Analysis of the Tffect of Community-based Treatment of Diabetic Nephropathy
HU Qing-zhi
Department of health，Baoan District Central Hosptial Affiliated to Cuangdong Medical College，Shenzhen，Guangdong Province，518102 China
[Abstract] Objective To study the effect of combination therapy intervention in patients with diabetic nephropathy albumin analysis of the community. Methods 315 patients from October 2010 to October 2015 in our hospital with type 2 diabetes as research subjects were randomly divided into intervention group and control group， the intervention group was treated with the combination therapy， the control group received conventional therapy， after the end of treatment to detect blood glucose， urinary albumin and renal function. Results Before treatment， the patients of the control group and intervention group fasting plasma glucose， 2-hour postprandial blood glucose and glycosylated hemoglobin difference was not statistically significant (P> 0.05). After treatment， patients in the intervention group fasting plasma glucose decreased to (5.61±0.45)mmol/L; fasting blood glucose decreased to control patients (6.34±0.72)mmol/L， before and after treatment， compared to the differences were statistically significant (P <0.05); intervention group patients with 2-hour postprandial blood glucose (6.61±0.66)mmol/L， glycosylated hemoglobin (6.12±0.77)% were lower than the control group， the difference was statistically significant (P<0.05)， the two groups before treatment， after comparison， the differences were statistically significant (P <0.05); before treatment， the control group and intervention group patients urine trace protein， serum creatinine， blood urea nitrogen， the endogenous creatinine Qing rate and homocysteine was no significant difference (P>0.05). After treatment， the control group patients urine protein， serum creatinine， blood urea nitrogen， endogenous creatinine clear and homocysteine and treatment before， the difference was not statistically significant (P>0.05); intervention group patients with urinary trace protein to (18.9±7.2)mg， serum creatinine decreased to(70±12)μmol/L， the dropped blood urea nitrogen (6.8±1.4)mmol/L， endogenous creatinine clear to (106±13)mL/min， homocysteine lowering to (13.98±6.7)mmol/L compared with before treatment， the differences were statistically significant (P<0.05)， the differences were statistically significant (P<0.05) compared with the control group after treatment. Conclusion Combination therapy， is able to control the blood glucose， to alleviate patients with kidney damage， delaying the process of diabetic nephropathy， can promote the use of community hospitals, 百拇医药(胡清芝)
[关键词] 综合疗法;糖尿病肾病;微量白蛋白
[中图分类号] R473.2 [文献标识码] A [文章编号] 1672-4062(2016)01(a)-0110-04
Combination Therapy Intervention Albumin Analysis of the Tffect of Community-based Treatment of Diabetic Nephropathy
HU Qing-zhi
Department of health，Baoan District Central Hosptial Affiliated to Cuangdong Medical College，Shenzhen，Guangdong Province，518102 China
[Abstract] Objective To study the effect of combination therapy intervention in patients with diabetic nephropathy albumin analysis of the community. Methods 315 patients from October 2010 to October 2015 in our hospital with type 2 diabetes as research subjects were randomly divided into intervention group and control group， the intervention group was treated with the combination therapy， the control group received conventional therapy， after the end of treatment to detect blood glucose， urinary albumin and renal function. Results Before treatment， the patients of the control group and intervention group fasting plasma glucose， 2-hour postprandial blood glucose and glycosylated hemoglobin difference was not statistically significant (P> 0.05). After treatment， patients in the intervention group fasting plasma glucose decreased to (5.61±0.45)mmol/L; fasting blood glucose decreased to control patients (6.34±0.72)mmol/L， before and after treatment， compared to the differences were statistically significant (P <0.05); intervention group patients with 2-hour postprandial blood glucose (6.61±0.66)mmol/L， glycosylated hemoglobin (6.12±0.77)% were lower than the control group， the difference was statistically significant (P<0.05)， the two groups before treatment， after comparison， the differences were statistically significant (P <0.05); before treatment， the control group and intervention group patients urine trace protein， serum creatinine， blood urea nitrogen， the endogenous creatinine Qing rate and homocysteine was no significant difference (P>0.05). After treatment， the control group patients urine protein， serum creatinine， blood urea nitrogen， endogenous creatinine clear and homocysteine and treatment before， the difference was not statistically significant (P>0.05); intervention group patients with urinary trace protein to (18.9±7.2)mg， serum creatinine decreased to(70±12)μmol/L， the dropped blood urea nitrogen (6.8±1.4)mmol/L， endogenous creatinine clear to (106±13)mL/min， homocysteine lowering to (13.98±6.7)mmol/L compared with before treatment， the differences were statistically significant (P<0.05)， the differences were statistically significant (P<0.05) compared with the control group after treatment. Conclusion Combination therapy， is able to control the blood glucose， to alleviate patients with kidney damage， delaying the process of diabetic nephropathy， can promote the use of community hospitals, 百拇医药(胡清芝)