胃肠道恶性肿瘤合并2型糖尿病的病理特征与血清CEA的关系(1)
[摘要] 目的 探讨胃肠道恶性肿瘤合并2型糖尿病的病理特征与血清CEA的关系。方法 收集在2014年8月—2015年11月在该院首次诊断的640例胃肠道恶性肿瘤患者，进行回顾性分析。在这些患者中，已经被确诊为合并2型糖尿病患者有87例，作为T2DM组，无合并糖尿病患者有553例，作为无合并DM组。比较CEA水平对被确诊为合并2型糖尿病的胃肠道恶性肿瘤患者在临床病理特点方面有何影响，同时分析影响胃肠道恶性肿瘤患者CEA水平的因素。结果 合并T2DM组在年龄、Fib等方面比无合并DM组高，而血红蛋白(HGB)、高密度脂蛋白胆固醇(HDL-C)相对较低(P<0.05)，同时肿瘤恶性度也较高(P<0.05)，患者恶性肿瘤中晚期比例高，但是没有统计学意义(P>0.05)。和无合并DM组相对比，合并T2DM组所检测出的CEA水平较高。同时合并T2DM组的胃肠道恶性肿瘤患者异常水平肿瘤指标浓度比例也比无合并DM组高。结论 血清CEA随着肿瘤浸润深度的不断加深，表达水平也不断增高。因此，CEA以及CAI19-9可以用来观察胃肠道恶性肿瘤患者的发展情况。CEA以及CAI19-9还可以作为胃肠道恶性肿瘤的筛选方案，用于高位人群筛查，从而实时、准确的检测胃肠道恶性肿瘤患者追踪预后、判断疗效以及病情变化。
[关键词] 胃肠道恶性肿瘤；2型糖尿病；病理特征；血清CEA
[中图分类号] R473 [文献标识码] A [文章编号] 1672-4062(2016)07(b)-0110-02
[Abstract] Objective To investigate the relationship between pathological features and serum CEA in patients with gastrointestinal cancer complicated with type 2 diabetes mellitus. Methods A retrospective analysis was performed on 640 patients with gastrointestinal cancer who were diagnosed in our hospital from November 2015 to August 2014. In these patients， 2 patients have been diagnosed with type 87 diabetes， as the T2DM group， 553 patients without diabetes， as the group without DM. To compare the effect of CEA level on the clinicopathological characteristics of patients with gastrointestinal malignancies diagnosed with type 2 diabetes， and to analyze the factors that affect the level of CEA in patients with gastrointestinal malignancies. Results Combining T2DM group in terms of age， FIB with DM group than high， and hemoglobin (Hgb)， high density lipoprotein cholesterol (HDL-C) relatively low (P < 0.05)， also tumor malignant degree is higher (P < 0.05)， a high proportion of patients with malignant tumor in advanced， but there isn't a statistical significance (P > 0.05). Compared with the DM group， the CEA level detected by the combined T2DM group was higher than that in the combined group. At the same time， the proportion of abnormal level of tumor markers in patients with T2DM group of gastrointestinal cancer patients was higher than that in the group without DM. Conclusion Serum CEA with the deepening of the depth of tumor invasion， the level of expression is also increasing. Therefore， CEA and CAI19-9 can be used to observe the development of gastrointestinal cancer patients. CEA and CAI19-9 can also as a screening program for malignant tumor of gastrointestinal tract for screening high， so the real-time and accurate detection of gastrointestinal malignant tumor patients to track outcomes， judging curative effect and the changes of the disease., http://www.100md.com(张华)
[关键词] 胃肠道恶性肿瘤；2型糖尿病；病理特征；血清CEA
[中图分类号] R473 [文献标识码] A [文章编号] 1672-4062(2016)07(b)-0110-02
[Abstract] Objective To investigate the relationship between pathological features and serum CEA in patients with gastrointestinal cancer complicated with type 2 diabetes mellitus. Methods A retrospective analysis was performed on 640 patients with gastrointestinal cancer who were diagnosed in our hospital from November 2015 to August 2014. In these patients， 2 patients have been diagnosed with type 87 diabetes， as the T2DM group， 553 patients without diabetes， as the group without DM. To compare the effect of CEA level on the clinicopathological characteristics of patients with gastrointestinal malignancies diagnosed with type 2 diabetes， and to analyze the factors that affect the level of CEA in patients with gastrointestinal malignancies. Results Combining T2DM group in terms of age， FIB with DM group than high， and hemoglobin (Hgb)， high density lipoprotein cholesterol (HDL-C) relatively low (P < 0.05)， also tumor malignant degree is higher (P < 0.05)， a high proportion of patients with malignant tumor in advanced， but there isn't a statistical significance (P > 0.05). Compared with the DM group， the CEA level detected by the combined T2DM group was higher than that in the combined group. At the same time， the proportion of abnormal level of tumor markers in patients with T2DM group of gastrointestinal cancer patients was higher than that in the group without DM. Conclusion Serum CEA with the deepening of the depth of tumor invasion， the level of expression is also increasing. Therefore， CEA and CAI19-9 can be used to observe the development of gastrointestinal cancer patients. CEA and CAI19-9 can also as a screening program for malignant tumor of gastrointestinal tract for screening high， so the real-time and accurate detection of gastrointestinal malignant tumor patients to track outcomes， judging curative effect and the changes of the disease., http://www.100md.com(张华)