联合检测尿碱性磷酸酶、γ—谷氨酰转肽酶在糖尿病肾病中的诊断应用价值(1)
[摘要] 目的 探讨尿碱性磷酸酶(U-ALP)、γ-谷氨酰转肽酶(U-GGT)联合检测在糖尿病肾病中的诊断应用价值。方法选取2016年1月—2017年5月该院收治的50例2型糖尿病肾病患者(研究组)以及同期来该院进行体检的50名健康者(健康对照组)为研究对象，分析两组患者U-ALP和U-GGT的检测结果。结果 研究组其U-ALP和U-GGT的检测结果分别为(12.30±4.18)U/L、(55.67±11.21)IU/L，相较于健康对照组，其含量明显增高，数据对比均差异有统计学意义(P<0.05)，其中两者联合检测的阳性率为66.00%，均高于单个检测的阳性率(P<0.05)。结论 尿碱性磷酸酶和γ-谷氨酰转肽酶均可用于2型糖尿病肾病的诊断中，但两者联合检测更能提高临床诊断的准确性，值得推广和应用。
[关键词] 尿碱性磷酸酶；γ-谷氨酰转肽酶；糖尿病肾病
[中图分类号] R587.2；R692 [文献标识码] A [文章编号] 1672-4062(2017)08(b)-0169-02
Application Value of Combined Test of Urine Alkaline Phosphatase and γ-glutamyltranspeptidase in Diagnosis of Diabetic Nephropathies
LUO Yun-zhi
Department of Clinical Laboratory， Changchun Hospital of Traditional Chinese Medicine， Changchun， Jilin Province， 130031 China
[Abstract] Objective To study the application value of combined test of urine alkaline phosphatase andγ-glutamyltranspeptidase in diagnosis of diabetic nephropathies. Methods 50 cases of type 2 diabetic nephropathies patients admitted and treated in our hospital from January 2016 to May 2017 were selected as the research group， 50 healthy people for physical examination in our hospital at the same period were selected as the healthy control group， and the test results of U-ALP and U-GGT of the two groups were analyzed. Results The test results of U-ALP and U-GGT were respectively(12.30±4.18)U/L and (55.67±11.21)IU/L， which were obviously improved compared with those in the healthy control group， and the differences were statistically significant(P<0.05)， and the positive rate of the combined test was 66.00%， which was higher than that of single test(P<0.05). Conclusion Both urine alkaline phosphatase andγ-glutamyltranspeptidase can diagnose the diabetic nephropathies， but the combined test can better improve the clinical diagnosis accuracy， and it is worth promotion and application.
[Key words] Urine alkaline phosphatase； γ-glutamyltranspeptidase； Diabetic nephropathies.
糖尿病腎病属于糖尿病的常见并发症之一，以蛋白尿、水肿以及肾功能不全为其主要临床表现，是引起终末期肾病的重要原因之一，严重时可诱发肾衰竭，甚至危及患者生命[1]。目前随着人口老龄化现象的加剧，糖尿病肾病的发病率也在明显上升，严重影响我国人民的身体健康[2]。针对该疾病，早发现、早治疗才能明显改善预后，延缓糖尿病肾病发展至终末期， 降低心脑血管疾病的发病率和病死率。但由于其早期指征不明显，需通过实验室指标的检测进行判断。相关研究指出[3]，多指标联合检测，更能提高临床的准确性。因此该研究为了进一步探讨尿碱性磷酸酶、γ-谷氨酰转肽酶联合检测在糖尿病肾病中的诊断应用价值，选取2016年1月—2017年5月该院收治的50例2型糖尿病肾病患者(研究组)以及同期来该院进行体检的50名健康者(健康对照组)为研究对象，现报道如下。
1 资料与方法
1.1 一般资料
选取该院收治的50例2型糖尿病肾病患者(研究组)以及同期来该院进行体检的50名健康者(健康对照组)为研究对象，糖尿病肾病的早期诊断标准[4]是持续性微量白蛋白尿(30～300 mg/24 h)。其中健康对照组男20名，女30名，平均年龄(60.7±10.5)岁，体质量(22.6±3.5)kg/m2，研究组男21例，女29例，平均年龄(61.1±10.2)岁，体质量(29.4±5.3)kg/m2，糖尿病病程为(12.0±8.8)年，两组患者基线资料对比差异无统计学意义(P>0.05)。该次研究经过该院伦理委员会的同意，且患者签署知情同意书。, http://www.100md.com(罗韫志)
[关键词] 尿碱性磷酸酶；γ-谷氨酰转肽酶；糖尿病肾病
[中图分类号] R587.2；R692 [文献标识码] A [文章编号] 1672-4062(2017)08(b)-0169-02
Application Value of Combined Test of Urine Alkaline Phosphatase and γ-glutamyltranspeptidase in Diagnosis of Diabetic Nephropathies
LUO Yun-zhi
Department of Clinical Laboratory， Changchun Hospital of Traditional Chinese Medicine， Changchun， Jilin Province， 130031 China
[Abstract] Objective To study the application value of combined test of urine alkaline phosphatase andγ-glutamyltranspeptidase in diagnosis of diabetic nephropathies. Methods 50 cases of type 2 diabetic nephropathies patients admitted and treated in our hospital from January 2016 to May 2017 were selected as the research group， 50 healthy people for physical examination in our hospital at the same period were selected as the healthy control group， and the test results of U-ALP and U-GGT of the two groups were analyzed. Results The test results of U-ALP and U-GGT were respectively(12.30±4.18)U/L and (55.67±11.21)IU/L， which were obviously improved compared with those in the healthy control group， and the differences were statistically significant(P<0.05)， and the positive rate of the combined test was 66.00%， which was higher than that of single test(P<0.05). Conclusion Both urine alkaline phosphatase andγ-glutamyltranspeptidase can diagnose the diabetic nephropathies， but the combined test can better improve the clinical diagnosis accuracy， and it is worth promotion and application.
[Key words] Urine alkaline phosphatase； γ-glutamyltranspeptidase； Diabetic nephropathies.
糖尿病腎病属于糖尿病的常见并发症之一，以蛋白尿、水肿以及肾功能不全为其主要临床表现，是引起终末期肾病的重要原因之一，严重时可诱发肾衰竭，甚至危及患者生命[1]。目前随着人口老龄化现象的加剧，糖尿病肾病的发病率也在明显上升，严重影响我国人民的身体健康[2]。针对该疾病，早发现、早治疗才能明显改善预后，延缓糖尿病肾病发展至终末期， 降低心脑血管疾病的发病率和病死率。但由于其早期指征不明显，需通过实验室指标的检测进行判断。相关研究指出[3]，多指标联合检测，更能提高临床的准确性。因此该研究为了进一步探讨尿碱性磷酸酶、γ-谷氨酰转肽酶联合检测在糖尿病肾病中的诊断应用价值，选取2016年1月—2017年5月该院收治的50例2型糖尿病肾病患者(研究组)以及同期来该院进行体检的50名健康者(健康对照组)为研究对象，现报道如下。
1 资料与方法
1.1 一般资料
选取该院收治的50例2型糖尿病肾病患者(研究组)以及同期来该院进行体检的50名健康者(健康对照组)为研究对象，糖尿病肾病的早期诊断标准[4]是持续性微量白蛋白尿(30～300 mg/24 h)。其中健康对照组男20名，女30名，平均年龄(60.7±10.5)岁，体质量(22.6±3.5)kg/m2，研究组男21例，女29例，平均年龄(61.1±10.2)岁，体质量(29.4±5.3)kg/m2，糖尿病病程为(12.0±8.8)年，两组患者基线资料对比差异无统计学意义(P>0.05)。该次研究经过该院伦理委员会的同意，且患者签署知情同意书。, http://www.100md.com(罗韫志)