糖尿病患者早期肾损伤采用胱抑素C联合尿RBP检测的诊断意义分析(1)
[摘要] 目的 研究糖尿病患者早期肾损伤使用胱抑素C联合尿RBP检测的诊断意义。 方法 文章所选择的糖尿病患者一共135例，纳入的时间为2017年11月—2018年11月，将其列为该次研究的研究组，对其基本资料进行前瞻性分析，其中，单纯糖尿病的67例作为DM组，早期肾损伤的68例为DN组，随机抽取70名同一时段来该院体检的正常人为常规组。分别抽取3组清晨开腹时的血液及尿液为检测标本，检测分析胱抑素C、尿RBP，观察其胱抑素C、尿RBP水平及联合检测的灵敏性。结果 研究组胱抑素C、尿RBP水平高于常规组，差异有统计学意义(P<0.05);DN组胱抑素C、尿RBP显著高于DM组，两组比较差异有统计学意义(P<0.05);DM组、DN组在胱抑素C、尿RBP联合检测下阳性检测率显著提高(P<0.05)。 结论 胱抑素C联合尿RBP检测糖尿病患者早期肾损伤具有较高的灵敏性，临床诊断价值高，值得推广。
[关键词] 糖尿病患者;早期肾损伤;胱抑素C;尿RBP;价值
[中图分类号] R587.2 [文献标识码] A [文章编号] 1672-4062(2019)02(b)-0061-03
Diagnostic Significance of Cystatin C Combined with Urinary RBP Detection in Early Renal Injury in Diabetic Patients
LIU De-yang
Department of Clinical Laboratory， Yankuang Group Co， Ltd， Zoucheng， Shandong Province， 273500 China
[Abstract] Objective To study the diagnostic value of cystatin C combined with urinary RBP in early renal injury in diabetic patients. Methods A total of 135 patients with diabetes were enrolled in the study. The time of enrollment was from November 2017 to November 2018. The study group was included in the study， and the basic data were prospectively analyzed. Among them， diabetes was the only one. 67 patients with DM group and 68 patients with early renal injury were enrolled in the DN group. 70 normal patients who came to our hospital for the same period of time were randomly selected. The blood and urine of three groups of morning laparotomy were taken as test samples， and cystatin C and urinary RBP were detected and analyzed， and the sensitivity of cystatin C， urinary RBP and joint detection were observed. Results The levels of Cystatin C and urinary RBP in the study group were significantly higher than those in the conventional group. The difference was statistically significant (P<0.05). Cystatin C and urinary RBP in the DN group were significantly higher than those in the DM group. Statistical significance(P<0.05); DM group and DN group showed a significant increase in the positive detection rate of cystatin C and urinary RBP (P<0.05). Conclusion Cystatin C combined with urinary RBP detection of early renal injury in diabetic patients of high sensitivity， high clinical diagnostic value， worth promoting.
[Key words] Diabetic patients; Early kidney injury; Cystatin C; Urine RBP; Value
近些年來，随着经济水平的不断上升，人们的饮食结构有了很大的变化，糖尿病(DM)的发病率也在逐年提高，其具有致残率高、致死率高等特点[1]。糖尿病肾病(DN)是糖尿病的一种并发症状，其早期不易被发现，会使患者错过治疗的最佳时期[2]。当前，检测糖尿病肾病的指标主要有尿素氮、肌酐等，但其敏感性相对较低，检查时错误率较高。而随着医学水平的不断进步，有一些新的糖尿病肾病标志物出现，如胱抑素C(Cys-C)、尿视黄醇结合蛋白(RBP)等，其能够更明显的显示肾小球滤过率的变化情况[3]。为研究糖尿病患者早期肾损伤采用胱抑素C联合尿RBP检测的诊断意义，该文选取2017年11月—2018年11月该院收治的135例糖尿病患者及70名健康人为研究对象进行研究，现报道如下。, http://www.100md.com(刘德洋)
[关键词] 糖尿病患者;早期肾损伤;胱抑素C;尿RBP;价值
[中图分类号] R587.2 [文献标识码] A [文章编号] 1672-4062(2019)02(b)-0061-03
Diagnostic Significance of Cystatin C Combined with Urinary RBP Detection in Early Renal Injury in Diabetic Patients
LIU De-yang
Department of Clinical Laboratory， Yankuang Group Co， Ltd， Zoucheng， Shandong Province， 273500 China
[Abstract] Objective To study the diagnostic value of cystatin C combined with urinary RBP in early renal injury in diabetic patients. Methods A total of 135 patients with diabetes were enrolled in the study. The time of enrollment was from November 2017 to November 2018. The study group was included in the study， and the basic data were prospectively analyzed. Among them， diabetes was the only one. 67 patients with DM group and 68 patients with early renal injury were enrolled in the DN group. 70 normal patients who came to our hospital for the same period of time were randomly selected. The blood and urine of three groups of morning laparotomy were taken as test samples， and cystatin C and urinary RBP were detected and analyzed， and the sensitivity of cystatin C， urinary RBP and joint detection were observed. Results The levels of Cystatin C and urinary RBP in the study group were significantly higher than those in the conventional group. The difference was statistically significant (P<0.05). Cystatin C and urinary RBP in the DN group were significantly higher than those in the DM group. Statistical significance(P<0.05); DM group and DN group showed a significant increase in the positive detection rate of cystatin C and urinary RBP (P<0.05). Conclusion Cystatin C combined with urinary RBP detection of early renal injury in diabetic patients of high sensitivity， high clinical diagnostic value， worth promoting.
[Key words] Diabetic patients; Early kidney injury; Cystatin C; Urine RBP; Value
近些年來，随着经济水平的不断上升，人们的饮食结构有了很大的变化，糖尿病(DM)的发病率也在逐年提高，其具有致残率高、致死率高等特点[1]。糖尿病肾病(DN)是糖尿病的一种并发症状，其早期不易被发现，会使患者错过治疗的最佳时期[2]。当前，检测糖尿病肾病的指标主要有尿素氮、肌酐等，但其敏感性相对较低，检查时错误率较高。而随着医学水平的不断进步，有一些新的糖尿病肾病标志物出现，如胱抑素C(Cys-C)、尿视黄醇结合蛋白(RBP)等，其能够更明显的显示肾小球滤过率的变化情况[3]。为研究糖尿病患者早期肾损伤采用胱抑素C联合尿RBP检测的诊断意义，该文选取2017年11月—2018年11月该院收治的135例糖尿病患者及70名健康人为研究对象进行研究，现报道如下。, http://www.100md.com(刘德洋)