短期胰岛素泵强化降糖治疗对2型糖尿病患者胱抑素C及同型半胱氨酸的影响(1)
[摘要] 目的 评价短期胰岛素泵强化降糖治疗对2型糖尿病患者胱抑素C(Cys-C)及同型半胱氨酸(Hcy)的影响。方法 2017年9月—2018年9月间该院单纯2型糖尿病患者64例随机分为A组和B組，每组32例。A组短期胰岛素泵强化降糖治疗，B组预混胰岛素治疗，均治疗2周，并取同期该院健康体检人群40名为C组。观察治疗前后3组的空腹血糖(FPG)、餐后2 h血糖(2 hPBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、空腹胰岛素(INs)、空腹C肽、Cys-C和Hcy水平。结果 FPG、2 hPBG、HbA1c、TC、TG、HDL-C、LDL-C、INS、空腹C肽、Cys-C和Hcy水平比较：A组治疗前后差异有统计学意义(P<0.05);治疗前后B组除TG，HDL-C和LDL-C水平差异无统计学意义(P>0.05)，其余指标(P<0.05);治疗前3组均差异有统计学意义(P<0.05)，治疗后AB组以及BC组比较差异有统计学意义(P<0.05)，治疗后A组除FPG、2 hPBG、HbA1c和Cys-C水平与C组差异有统计学意义(P<0.05)，其余指标均与C组差异无统计学意义(P>0.05)。结论 对于2型糖尿病患者，短期胰岛素泵强化降糖治疗可明显降低患者FPG、2hPBG、HbA1c、TC、TG、LDL-C、INS、Cys-C和Hcy水平，提高HDL-C和空腹C肽水平，缓解患者糖尿病肾脏病变及微血管病变的影响，更好的指导临床工作。
[关键词] 胰岛素泵;降糖治疗;2型糖尿病;胱抑素C;同型半胱氨酸
[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062(2019)04(b)-0006-04
[Abstract] Objective To evaluate the effects of short-term insulin pump intensive glucose-lowering therapy on cystatin C (Cys-C) and homocysteine (Hcy) in patients with type 2 diabetes mellitus. Methods From september 2017 to Semtember 2018 64 patients with type 2 diabetes mellitus in our hospital were randomly divided into group A and group B， with 32 cases in each group. Group A short-term insulin pump intensive hypoglycemic therapy， group B premixed insulin treatment， were treated for 2 weeks， and 40 patients in our hospital for physical examination in the same period were group C. Fasting blood glucose (FPG)， postprandial 2-hour blood glucose (2 hPBG)， glycosylated hemoglobin (HbA1c)， total cholesterol (TC)， triglyceride (TG)， high-density lipoprotein (HDL-C)， Low density lipoprotein (LDL-C)， fasting insulin (INs)， fasting C-peptide， Cys-C and Hcy levels. Results The levels of FPG， 2 hPBG， HbA1c， TC， TG， HDL-C， LDL-C， INS， fasting C peptide， Cys-C and Hcy were significantly different between the two groups (P<0.05). There were no significant differences in the levels of TG， HDL-C and LDL-C in group B (P>0.05)， and other indicators were also significantly different (P<0.05). There were significant differences in the three groups before treatment (P<0.05). There were statistically significant differences between the AB group and the BC group after treatment (P<0.05). After treatment， the levels of FPG， 2 hPBG， HbA1c and Cys-C in group A were significantly different from those in group C (P<0.05). There was no significant difference between the two groups (P>0.05). Conclusion For patients with type 2 diabetes， short-term insulin pump intensive hypoglycemic therapy can significantly reduce the levels of FPG， 2 hPBG， HbA1c， TC， TG， LDL-C， INS， Cys-C and Hcy， and increase the levels of HDL-C and fasting C-peptide， alleviate the effects of diabetic nephropathy and microvascular disease in patients， and better guide clinical work., 百拇医药(刘效荣 侯娟 吴燕 张计划 刘彦娥)
[关键词] 胰岛素泵;降糖治疗;2型糖尿病;胱抑素C;同型半胱氨酸
[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062(2019)04(b)-0006-04
[Abstract] Objective To evaluate the effects of short-term insulin pump intensive glucose-lowering therapy on cystatin C (Cys-C) and homocysteine (Hcy) in patients with type 2 diabetes mellitus. Methods From september 2017 to Semtember 2018 64 patients with type 2 diabetes mellitus in our hospital were randomly divided into group A and group B， with 32 cases in each group. Group A short-term insulin pump intensive hypoglycemic therapy， group B premixed insulin treatment， were treated for 2 weeks， and 40 patients in our hospital for physical examination in the same period were group C. Fasting blood glucose (FPG)， postprandial 2-hour blood glucose (2 hPBG)， glycosylated hemoglobin (HbA1c)， total cholesterol (TC)， triglyceride (TG)， high-density lipoprotein (HDL-C)， Low density lipoprotein (LDL-C)， fasting insulin (INs)， fasting C-peptide， Cys-C and Hcy levels. Results The levels of FPG， 2 hPBG， HbA1c， TC， TG， HDL-C， LDL-C， INS， fasting C peptide， Cys-C and Hcy were significantly different between the two groups (P<0.05). There were no significant differences in the levels of TG， HDL-C and LDL-C in group B (P>0.05)， and other indicators were also significantly different (P<0.05). There were significant differences in the three groups before treatment (P<0.05). There were statistically significant differences between the AB group and the BC group after treatment (P<0.05). After treatment， the levels of FPG， 2 hPBG， HbA1c and Cys-C in group A were significantly different from those in group C (P<0.05). There was no significant difference between the two groups (P>0.05). Conclusion For patients with type 2 diabetes， short-term insulin pump intensive hypoglycemic therapy can significantly reduce the levels of FPG， 2 hPBG， HbA1c， TC， TG， LDL-C， INS， Cys-C and Hcy， and increase the levels of HDL-C and fasting C-peptide， alleviate the effects of diabetic nephropathy and microvascular disease in patients， and better guide clinical work., 百拇医药(刘效荣 侯娟 吴燕 张计划 刘彦娥)