2型糖尿病病程对干眼的影响(1)
[摘要] 目的 探讨2型糖尿病病程对干眼的影响。 方法 收集苏州大学附属第三医院2019年3—9月内分泌科住院患者中确诊为2型糖尿病的患者共101例202眼，其中糖尿病病程≤5年的有51例102眼(B组)，病程>5年的有50例100眼(C组)，另外收集同期无糖尿病健康体检者49例98眼(A组)，对比测量各组患者的泪膜破裂时间(BUT)、泪液分泌试验(SIt)、角膜荧光素染色(FL)评分，比较不同病程糖尿病患者之间干眼指标的差异。结果ABC 3组的 FL评分差异无统计学意义(P>0.05)，A组BUT为(6.99±2.15)s，B组为(6.86±2.03)s，C组为(5.97±1.56)s，A、B两组与C组相比差异有统计学意义(P(AvsC)=0.006，P(BvsC)=0.006);A组SIt为(7.4±1.8)mm，B组为(7.0±4.0)mm，C组为(5.9±2.4)mm，A、B两组与C组相比差异有统计学意义(P(AvsC)=0.009，P(BvsC)=0.032)。 结论 糖尿病干眼的发生与严重程度与糖尿病病程有关，当糖尿病病程>5年时，患者的干眼相关指标明显变差。
[关键词] 2型糖尿病;病程;干眼
[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062(2020)02(b)-0009-03
[Abstract] Objective To explore the effect of type 2 diabetes on dry eye. Methods A total of 101 patients of 202 eyes with type 2 diabetes were diagnosed among inpatients in the endocrinology department of the Third Affiliated Hospital of Soochow University from March 2019 to September 2019. Of these， 51 cases of 102 eyes with a course of diabetes ≤ 5 years (group B)， 50 patients with 100 eyes (group C) with a course of disease> 5 years， and 49 patients with 98 eyes (group A) with no diabetes during the same period were collected， and the tear film rupture time (BUT) and tear fluid of the patients in each group were compared and measured. The secretory test (SIt) and corneal fluorescein staining (FL) scores were used to compare the differences in dry eye indicators among patients with different durations of diabetes. Results There was no significant difference in FL scores among the three groups of ABC (P>0.05). The BUT in group A was (6.99± 2.15) s， group B was (6.86±2.03) s， and group C was (5.97±1.56) s. Compared with group C， the differences between group A and B are significantly statistically significant. P(AvsC)=0.006， P(BvsC)=0.006; SIt in group A was (7.4±1.8) mm， and group B was (7.0±4.0) mm， group C was (5.9±2.4) mm， and the differences between groups A and B compared with group C were statistically significant(P(AvsC)=0.009， P(BvsC)=0.032. Conclusion The occurrence and severity of diabetic dry eye are related to the duration of diabetes. When the duration of diabetes is more than 5 years， the dry eye-related indicators of patients become significantly worse.
[Key words] Type 2 diabetes; Course of disease; Dry eye
干眼是淚液和眼表的一种多因素疾病，主要表现为眼部不适感、视力障碍、泪膜不稳定等症状[1]。干眼较为严重时会影响视力，影响正常的生活和工作。糖尿病则是目前最常见的慢性病之一，会引起各种慢性代谢性疾病如糖尿病视网膜病变、糖尿病肾病、糖尿病周围神经病变等。越来越多的研究表明[2]，糖尿病与干眼之间存在紧密的联系，尤其是在亚洲地区，糖尿病是导致干眼的主要危险因素。我国目前的干眼病人基数庞大，因此，探究糖尿病相关因素对干眼的影响对解决这一公共卫生问题有较为深远的社会意义。多项研究指出，糖尿病患者干眼症发生可能与血糖控制不佳有关，而糖尿病病程与干眼的相关性目前尚无明确定论，该研究通过比对不同病程糖尿病患者的眼表情况，旨在探寻糖尿病病程对患者眼表功能的影响。, 百拇医药(吴志航 李淑婷 吴靖怡 潘恂)
[关键词] 2型糖尿病;病程;干眼
[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062(2020)02(b)-0009-03
[Abstract] Objective To explore the effect of type 2 diabetes on dry eye. Methods A total of 101 patients of 202 eyes with type 2 diabetes were diagnosed among inpatients in the endocrinology department of the Third Affiliated Hospital of Soochow University from March 2019 to September 2019. Of these， 51 cases of 102 eyes with a course of diabetes ≤ 5 years (group B)， 50 patients with 100 eyes (group C) with a course of disease> 5 years， and 49 patients with 98 eyes (group A) with no diabetes during the same period were collected， and the tear film rupture time (BUT) and tear fluid of the patients in each group were compared and measured. The secretory test (SIt) and corneal fluorescein staining (FL) scores were used to compare the differences in dry eye indicators among patients with different durations of diabetes. Results There was no significant difference in FL scores among the three groups of ABC (P>0.05). The BUT in group A was (6.99± 2.15) s， group B was (6.86±2.03) s， and group C was (5.97±1.56) s. Compared with group C， the differences between group A and B are significantly statistically significant. P(AvsC)=0.006， P(BvsC)=0.006; SIt in group A was (7.4±1.8) mm， and group B was (7.0±4.0) mm， group C was (5.9±2.4) mm， and the differences between groups A and B compared with group C were statistically significant(P(AvsC)=0.009， P(BvsC)=0.032. Conclusion The occurrence and severity of diabetic dry eye are related to the duration of diabetes. When the duration of diabetes is more than 5 years， the dry eye-related indicators of patients become significantly worse.
[Key words] Type 2 diabetes; Course of disease; Dry eye
干眼是淚液和眼表的一种多因素疾病，主要表现为眼部不适感、视力障碍、泪膜不稳定等症状[1]。干眼较为严重时会影响视力，影响正常的生活和工作。糖尿病则是目前最常见的慢性病之一，会引起各种慢性代谢性疾病如糖尿病视网膜病变、糖尿病肾病、糖尿病周围神经病变等。越来越多的研究表明[2]，糖尿病与干眼之间存在紧密的联系，尤其是在亚洲地区，糖尿病是导致干眼的主要危险因素。我国目前的干眼病人基数庞大，因此，探究糖尿病相关因素对干眼的影响对解决这一公共卫生问题有较为深远的社会意义。多项研究指出，糖尿病患者干眼症发生可能与血糖控制不佳有关，而糖尿病病程与干眼的相关性目前尚无明确定论，该研究通过比对不同病程糖尿病患者的眼表情况，旨在探寻糖尿病病程对患者眼表功能的影响。, 百拇医药(吴志航 李淑婷 吴靖怡 潘恂)