津力达颗粒联合二甲双胍治疗对妊娠期糖尿病患者的影响(1)
[摘要] 目的 研究津力达颗粒联合二甲双胍治疗对妊娠期糖尿病患者的影响。方法 选择在2018年1月—2019年1月该院接受治疗的52例妊娠期糖尿病患者，随机分为观察组和对照组，观察组患者采取津力达颗粒联合二甲双胍的治疗方式，对照组患者只使用二甲双胍进行治疗。经过治疗干预后比较两组患者糖化血红蛋白、空腹血糖、餐后2 h血糖的含量情况，并统计产妇并发症和新生儿不良结局的情况。结果 观察组空腹血糖、餐后2 h血糖、糖化血红蛋白分别为：(4.23±0.56)mmol/L、(3.67±1.05)mmol/L、(4.67±0.56)%，均显著优于对照组，差异有统计学意义(P<0.05);观察组患者并发症总发生率为23.08%，显著低于对照组53.85%，差异有统计学意义(P<0.05);观察组新生儿黄疸、巨大儿、呼吸窘迫分别为5(19.23%)、2(7.69%)、0(0.00%)，均显著低于对照组，差异有统计学意义(P<0.05)。结论 津力达颗粒联合二甲双胍联合用药可以改善患者的血糖情况，并在一定程度上降低产妇并发症的发生率，改善新生儿结局。
[关键词] 津力达颗粒;二甲双胍;妊娠期糖尿病
[中图分类号] R587 [文献标识码] A [文章编号] 1672-4062(2020)08(b)-0065-03
[Abstract] Objective To study the effect of Jinlida granule combined with metformin on gestational diabetes. Methods 52 patients with gestational diabetes who were treated in the hospital were randomly divided into observation and control groups from January 2018 to January 2019. Patients in the observation group were treated with Jinlida granules combined with metformin， and patients in the control group were treated with metformin only. After treatment and intervention， the content of glycated hemoglobin， fasting blood glucose， and bloord glucose 2 h after a meal were compared between the two groups， and the maternal complications and adverse neonatal outcomes were counted. Results The fasting blood glucose， 2 h postprandial blood glucose， and glycated hemoglobin in the observation group were(4.23±0.56)mmol/L，(3.67±1.05)mmol/L，(4.67±0.56)%， which were significantly better than the control group， the difference was statistically significant(P<0.05); complications total incidence rate in the observation group was 23.08%， significantly lower than the control group 53.85%， the difference was statistically significant(P<0.05); the observation group neonatal jaundice， giant children， respiratory distress were 5(19.23%)， 2(7.69%)，0(0.00%)， significantly lower than the control group， the difference was statistically significant(P<0.05). Conclusion The combined use of Jinlida granules and metformin can improve the blood glucose of patients， reduce the incidence of maternal complications to a certain extent， and improve neonatal outcomes.
[Key words] Jinlida granules; Metformin; Gestational diabetes
妊娠期糖尿病是指患者在以往并無糖耐量异常或是糖尿病的情况，而在妊娠期首次出现糖尿病，是产科较为常见的疾病。若不及时控制患者血糖则容易造成高血压、羊水过多等情况，且对胎儿结局也有一定的不利影响，增加新生儿出现呼吸窘迫、巨大儿等概率。对于糖尿病的治疗有胰岛素、双胍类、磺脲类等多种药物，但由于妊娠期妇女的特殊情况，且多数药物不良反应较大，因此在用药时要格外注意。妊娠期糖尿病使用的西药有二甲双胍、格列美脲、阿卡波糖片等，最常用的为二甲双胍，此外，一些中药复方剂如津力达颗粒等，也可以用于糖尿病的治疗[1]。津力达颗粒含有人参、黄精、淫羊藿等药物，具有益气养阴、健脾益津等作用，且不良反应较少，在临床中应用较多。面对妊娠期患者的特殊性，在用药时需更加注意药物的剂量和不良反应，采取联合用药的方式以减少单一药物的使用风险。该文于2018年1月—2019年1月收治的52例患者，主要研究津力达颗粒联合二甲双胍治疗对妊娠期糖尿病患者的影响，现报道如下。, 百拇医药(张静 杨廷勇)
[关键词] 津力达颗粒;二甲双胍;妊娠期糖尿病
[中图分类号] R587 [文献标识码] A [文章编号] 1672-4062(2020)08(b)-0065-03
[Abstract] Objective To study the effect of Jinlida granule combined with metformin on gestational diabetes. Methods 52 patients with gestational diabetes who were treated in the hospital were randomly divided into observation and control groups from January 2018 to January 2019. Patients in the observation group were treated with Jinlida granules combined with metformin， and patients in the control group were treated with metformin only. After treatment and intervention， the content of glycated hemoglobin， fasting blood glucose， and bloord glucose 2 h after a meal were compared between the two groups， and the maternal complications and adverse neonatal outcomes were counted. Results The fasting blood glucose， 2 h postprandial blood glucose， and glycated hemoglobin in the observation group were(4.23±0.56)mmol/L，(3.67±1.05)mmol/L，(4.67±0.56)%， which were significantly better than the control group， the difference was statistically significant(P<0.05); complications total incidence rate in the observation group was 23.08%， significantly lower than the control group 53.85%， the difference was statistically significant(P<0.05); the observation group neonatal jaundice， giant children， respiratory distress were 5(19.23%)， 2(7.69%)，0(0.00%)， significantly lower than the control group， the difference was statistically significant(P<0.05). Conclusion The combined use of Jinlida granules and metformin can improve the blood glucose of patients， reduce the incidence of maternal complications to a certain extent， and improve neonatal outcomes.
[Key words] Jinlida granules; Metformin; Gestational diabetes
妊娠期糖尿病是指患者在以往并無糖耐量异常或是糖尿病的情况，而在妊娠期首次出现糖尿病，是产科较为常见的疾病。若不及时控制患者血糖则容易造成高血压、羊水过多等情况，且对胎儿结局也有一定的不利影响，增加新生儿出现呼吸窘迫、巨大儿等概率。对于糖尿病的治疗有胰岛素、双胍类、磺脲类等多种药物，但由于妊娠期妇女的特殊情况，且多数药物不良反应较大，因此在用药时要格外注意。妊娠期糖尿病使用的西药有二甲双胍、格列美脲、阿卡波糖片等，最常用的为二甲双胍，此外，一些中药复方剂如津力达颗粒等，也可以用于糖尿病的治疗[1]。津力达颗粒含有人参、黄精、淫羊藿等药物，具有益气养阴、健脾益津等作用，且不良反应较少，在临床中应用较多。面对妊娠期患者的特殊性，在用药时需更加注意药物的剂量和不良反应，采取联合用药的方式以减少单一药物的使用风险。该文于2018年1月—2019年1月收治的52例患者，主要研究津力达颗粒联合二甲双胍治疗对妊娠期糖尿病患者的影响，现报道如下。, 百拇医药(张静 杨廷勇)