生化检测对糖尿病肾病早期临床诊断的临床价值分析(1)
[摘要] 目的 探究生化检测对糖尿病肾病早期临床诊断的临床价值。方法 选取该院2018年2月—2019年2月收治的82例糖尿病肾病早期患者为研究组，另选同期健康体检者82名为对照组，分别对两组进行血尿素氮(BUN)、肌酐(Cr)、视黄醇结合蛋白(RBP)、血胱抑素C(CysC)等生化指标检测，分析各项指标对糖尿病肾病早期临床诊断的临床价值。结果 研究组检测指标水平均高于对照组，差异有统计学意义(P<0.05);CysC+RBP+Cr+BUN联合检测阳性率为95.1%，均高于单项指标阳性率，差异有统计学意义(P<0.05)。结论 对于糖尿病肾病患者及早进行相应的指标检测，采取有效的措施，改善预后。
[关键词] 生化检测;糖尿病肾病早期;临床价值;临床应用
[中图分类号] R59 [文献标识码] A [文章编号] 1672-4062(2020)09(a)-0057-03
[Abstract] Objective To explore the clinical value of biochemical detection for early clinical diagnosis of diabetic nephropathy. Methods 82 case with early diabetic nephropathy admitted in the hospital in February 2018 and February 2019 were selected as the study group， and 82 peple with healthy physical examination during the same period were selected as the control group. The two groups were treated with blood urea nitrogen (BUN)， Creatinine (Cr)， retinol-binding protein (RBP)， blood cystatin C (CysC) and other biochemical indicators， analyze the clinical value of each indicator in the early clinical diagnosis of diabetic nephropathy. Results The detection index level of the study group was higher than that of the control group， and the difference was statistically significant (P<0.05); the positive rate of CysC+RBP+Cr+BUN combined detection was 95.1%， which was higher than the positive rate of individual indicators， and the difference was statistically significant(P<0.05). Conclusion For patients with diabetic nephropathy， carry out corresponding index detection as soon as possible， and take effective measures to improve the prognosis.
[Key words] Biochemical testing; Early diabetic nephropathy; Clinical value; Clinical application
糖尿病是威脅人类健康的一类公共健康问题，随着疾病的进展不仅对患者的心、肾、眼等脏器造成损伤，还会影响患者的机体代谢功能[1-2]。长期的代谢紊乱造成患者肾实质的损伤，导致糖尿病肾病的形成，随着病情的进展，引起慢性肾衰竭、肾动脉硬化及尿毒症，增加患者病死率[3-4]。糖尿病肾病为临床多发的糖尿病并发症，易引发尿毒症，病情严重者会有生命威胁。早期糖尿病肾病患者无特殊临床表现，因此早期进行生化指标检测对糖尿病肾病患者具有重要价值，能够及早的了解疾病发展程度，为进一步的诊治提供有力依据。同时通过对糖尿病肾病患者的早期诊断与合理治疗能延缓患者的病情发展。该次研究选取2018年2月—2019年2月的82例糖尿病早期患者与82名健康体检者，对生化检测对糖尿病肾病早期的应用及价值进行探讨，现报道如下。
1 资料与方法
1.1 一般资料
收集该院收治的82例糖尿病肾病早期患者为研究组，另选同期健康体检人员82名为对照组。其中对照组男性41名，女性41名，年龄28～72岁，平均年龄(50.0±3.2)岁。研究组男性患者42例，女性患者40例;年龄29～74岁，平均年龄(51.5±2.0)岁。研究组纳入标准：均符合糖尿病肾病诊断标准;无原发性肾病;无心脏、甲状腺疾病;无恶性肿瘤;近期未曾使用激素类药物者。两组患者年龄、性别表现相近，差异无统计学意义(P>0.05)。所有患者及其家属均对该研究知情同意，并签署知情同意书，该研究已获该院伦理委员会批准。
1.2 方法
1.2.1 样本采集 采集受试者次日清晨空腹静脉血5 mL，进行高速离心，分离血浆，取得上层血清，储存于-35℃处备用待检。同时用一次性尿杯采集清晨中段尿待测。, 百拇医药(王华磊)
[关键词] 生化检测;糖尿病肾病早期;临床价值;临床应用
[中图分类号] R59 [文献标识码] A [文章编号] 1672-4062(2020)09(a)-0057-03
[Abstract] Objective To explore the clinical value of biochemical detection for early clinical diagnosis of diabetic nephropathy. Methods 82 case with early diabetic nephropathy admitted in the hospital in February 2018 and February 2019 were selected as the study group， and 82 peple with healthy physical examination during the same period were selected as the control group. The two groups were treated with blood urea nitrogen (BUN)， Creatinine (Cr)， retinol-binding protein (RBP)， blood cystatin C (CysC) and other biochemical indicators， analyze the clinical value of each indicator in the early clinical diagnosis of diabetic nephropathy. Results The detection index level of the study group was higher than that of the control group， and the difference was statistically significant (P<0.05); the positive rate of CysC+RBP+Cr+BUN combined detection was 95.1%， which was higher than the positive rate of individual indicators， and the difference was statistically significant(P<0.05). Conclusion For patients with diabetic nephropathy， carry out corresponding index detection as soon as possible， and take effective measures to improve the prognosis.
[Key words] Biochemical testing; Early diabetic nephropathy; Clinical value; Clinical application
糖尿病是威脅人类健康的一类公共健康问题，随着疾病的进展不仅对患者的心、肾、眼等脏器造成损伤，还会影响患者的机体代谢功能[1-2]。长期的代谢紊乱造成患者肾实质的损伤，导致糖尿病肾病的形成，随着病情的进展，引起慢性肾衰竭、肾动脉硬化及尿毒症，增加患者病死率[3-4]。糖尿病肾病为临床多发的糖尿病并发症，易引发尿毒症，病情严重者会有生命威胁。早期糖尿病肾病患者无特殊临床表现，因此早期进行生化指标检测对糖尿病肾病患者具有重要价值，能够及早的了解疾病发展程度，为进一步的诊治提供有力依据。同时通过对糖尿病肾病患者的早期诊断与合理治疗能延缓患者的病情发展。该次研究选取2018年2月—2019年2月的82例糖尿病早期患者与82名健康体检者，对生化检测对糖尿病肾病早期的应用及价值进行探讨，现报道如下。
1 资料与方法
1.1 一般资料
收集该院收治的82例糖尿病肾病早期患者为研究组，另选同期健康体检人员82名为对照组。其中对照组男性41名，女性41名，年龄28～72岁，平均年龄(50.0±3.2)岁。研究组男性患者42例，女性患者40例;年龄29～74岁，平均年龄(51.5±2.0)岁。研究组纳入标准：均符合糖尿病肾病诊断标准;无原发性肾病;无心脏、甲状腺疾病;无恶性肿瘤;近期未曾使用激素类药物者。两组患者年龄、性别表现相近，差异无统计学意义(P>0.05)。所有患者及其家属均对该研究知情同意，并签署知情同意书，该研究已获该院伦理委员会批准。
1.2 方法
1.2.1 样本采集 采集受试者次日清晨空腹静脉血5 mL，进行高速离心，分离血浆，取得上层血清，储存于-35℃处备用待检。同时用一次性尿杯采集清晨中段尿待测。, 百拇医药(王华磊)