子痫前期病人血清Gas6和SDF-1水平变化及意义(2)
ConclusionPatients with preeclampsia have an increased serum level of Gas6 and a decreased serum level of SDF-1, which are correlated with the severity of disease.[KEY WORDS]eclampsia; growth arrest specific gene 6; chemokine CXCL12; chemokines
子痫前期是导致产妇及婴儿死亡的主要因素之一[1]。近年来该病发病率呈上升趋势[2-3]。研究发现,炎症反应及血管内皮损伤在子痫前期发病中发挥重要作用[4]。生长停滞特异基因6(Gas6)作为新近发现的生长因子,在调控细胞增殖、分裂、生长、凋亡中发挥重要作用[5],Gas6可通过调控血管新生、血小板聚集等而加剧组织局部氧化应激及炎症反
应[6] ......
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