Conclusion There are similar clinical features between AL patients with MLL translocations and MLL amplifications. The MLL gene develops gain-of-function abnormalities in the pathogenesis of AL.

    [KEY WORDS] leukemia， biphenotypic， acute; translocation， genetic; gene amplification

    急性白血病(AL)伴混合系列白血病(MLL)基因重排是常見的重现性细胞遗传学异常。常规细胞遗传学分析(CCA)检出11q23异常占全部AL病人的5%～10%。MLL基因异常的形式较多，包括易位、扩增、部分串连重复(PTD)和PHD结构域缺失等 [1-3] ......