[摘要] 天冬氨酰-(天冬酰胺酰)β-羟化酶(ASPH)是α-酮戊二酸依赖性双加氧酶，催化天冬氨酰和天冬酰胺基残基的羟化。ASPH在肝细胞癌和肝内胆管癌中均有表达，对二者的发生和发展有作用。本文主要对ASPH的结构和功能及其作用机制的研究进展进行综述。

    [关键词] 天冬氨酰-(天冬酰胺酰)β-羟化酶;α酮戊二酸依赖性双加氧酶FTO;肝肿瘤;受体，Notch;综述

    [中图分类号] R345;R735.7 [文献标志码] A [文章编号] 2096-5532(2020)02-0248-05

    doi：10.11712/jms.2096-5532.2020.56.101 [开放科学(资源服务)标识码(OSID)]

    [网络出版] http：//kns.cnki.net/kcms/detail/37.1517.R.20200521.1527.002.html;2020-05-22 08：50

    [ABSTRACT] Aspartyl-(asparaginyl)-β-hydroxylase (ASPH) is a α-ketoglutarate-dependent dioxygenase and catalyzes the hydroxylation of aspartyl and asparaginyl residues. ASPH is expressed in both hepatocellular carcinoma and intrahepatic cholangiocarcinoma and has an effect on the development and progression of these two diseases. This article reviews the research advances in the structure ......