【摘 要】 目的观察胃康舒宁对大鼠胃癌前病变的治疗作用，为临床应用提供依据。方法将60只Wistar大鼠随机分为4组，正常组、模型组、维酶素组和胃康舒宁组，采用饮用N-甲基-N-亚硝基-N-硝基胍(MNNG)建立大鼠胃癌前病变模型，用维酶素和胃康舒宁治疗12周后，观察各组实验大鼠胃黏膜病理形态及细胞凋亡指数的变化。结果与模型组大鼠相比，用药组大鼠的一般情况、胃黏膜萎缩、肠上皮化生和非典型增生状况均有明显改善，胃黏膜细胞凋亡指数明显提高，以胃康舒宁组明显优于维酶素组。结论胃康舒宁对大鼠胃癌前病变具有良好的治疗和逆转作用，其疗效优于维酶素。

    【关键词】 胃康舒宁 胃癌前病变 大鼠

    A Study on Weikangshu'ning on Influence on Gastric Mucosal Pathology and Apoptosisindex in Rats of Precancer Lesions of Gastric Carinnoma

    Liu Wanggen，Wang Qi，Feng Li

    Henan College of Traditional Chinese Medicine

    【Abstract】 Objective To observe curative effects of Weikangshu'ning on Precancer Lesions of Gastric Carinnoma (PLGC) in Rats,and offer the experimental foundation for clinical applying. Methods 60 Wistar rats were randomly divided into Control group, PLGC group, Vitacoenzyme group and Weikangshu'ning group. Models ofPLGC were induced by N-methly-N-nitro-N- nitrosoguanidine(MNNG), Gastric Mucosal Pathology and Apoptosisindex were examined in each group respectively. Results When compared with the PLGC group ......