[摘要]本文综述了5-HT受体亚型与抑郁症的关系及分类，并重点综述了5-HT₂受体拮抗剂抗抑郁作用的机制及其新产品的研究与开发。表明中枢神经系统的5-HT_2AR 与血小板中5-HT_2AR药理学特性相似，指出了血小板5-HT_2AR密度为抑郁症的状态指标。

    关键词：抑郁症 抗抑郁药 5-HT 5-HT₂受体 拮抗剂

    Research and Development of 5-HT₂ Receptors Antagonists,a New Class of Antidepressants

    ZHANG Guo-liang, WANG Xing-yong, ZHANG Gui-sen

    [Abstract]In this paper, not only the relationship of 5-HT receptors subtypes and depression, and the class of them were highlighted,but also the acting mechanism and research and development of this class of antidepressants were importantly summarized.It indicated the pharmacological comparability of 5-HT_2A receptor in the CNS and hematoblast. The densities of this receptor in blood platelet acting as stating target of the depression were also point out.

    [Keywords]depression;Antidepressants;5-HT;5-HT₂ receptors; Antagonists

    中图分类号：R971.43 文献标识码：B 文章编号：1672-5085(2007)3-0057-03

    15-HT受体与抑郁症国外报道抑郁症的男性终生患病率为5%～12% ......