[摘要]目的分析注射用阿莫西林钠克拉维酸钾配伍液变色和沉淀的原因，提出预防措施，确保临床用药安全有效。方法查阅相关文献，从中获取阿莫西林钠和克拉维酸钾的稳定性资料，解释变色沉淀现象。结果本品配伍液变色与阿莫西林钠和克拉维酸钾在一定条件下(水分、温度、光线、溶媒及pH值、时间)分解有关；沉淀与配伍时温度低、pH值低、浓度高有关。结论本品应密闭，在凉暗干燥处(≤20℃)保存，用0.9%氯化钠注射液(pH值6.5～7.0)溶解，立即稀释至1.2g/100ml，并在2h内(20℃以下暗处)完成整个输液过程。

    关键词：阿莫西林钠克拉维酸钾 配伍液

    [Abstract]Objectives： To analyze the causes of the color turning and precipitation phenomena of for-injection Amoxicillin Sodium and Clavulanate Potassium and propose corresponding measures for a safe clinic consumption of the product. Methods： Summarize the existing researches on the stability of Amoxicillin Sodium and Clavulanate Potassium for Injection from an extensive literature review. Results： It is fund that the color turning and precipitation phenomena of Amoxicillin Sodium and Clavulanate Potassium are related to the certain conditions ( e.g. moisture content, temperature, light, menstruum, PH value and time) under which the process takes place.Conclusion： In order to ensure a safely clinic consumption, the Amoxicillin Sodium and Clavulanate Potassium for injection should be maintained in a cool (≤20 ℃), dry, hermetic, and light-free condition, and be used within 2 hours once after its dilution to 1.2g/100ml within0.9% common salt injection (pH between 6.5 and 7.0). ......