纳洛酮脑保护作用的研究现状(3)
2 Elaine T、 Malcolm B、 et al. Increased intracerebral excitatory amino acids and nitric oxide after hypothermic circulatory arrest. Ann Thorc Surg, 1999, 67:371~376
3 Tymianski M、Tator CH.Normal and abnormal calcium homeostasis in neurons: a basis for the pathophysiology of traumatic and ischemic central nervous system injury. Neurosurg, 1996, 38:1176~1195
4 Fade AI、Demediuk P、Panter SS、et al. The role of ecitatory amino acids and NMDA receotors in traumatic head injury.Science, 1989, 244:798~800
, http://www.100md.com
5 Rysard Przewlocki et al.Opioid Enhancement of Calcium Oscillations and Burst Events Involving NMDA Receptors and L-Type Calcium Channels in Cultured Hippocampal Neurons.The Journal of Neuroscience, 1999, 19(22): 9705~9715
6 JC Yang、J Shan、 et al.Morphine and methadone have different effect on calcium channel currents in neuroblastoma cells.Brain Research, 2000, 870:199~203
7 Chun-Jung Chen、 Fu-Chou Cheng、 et al.Effects of naloxone on lactate, pyruvate metabolism and antioxidant enzyme activity in rat cerebral ischemia/reperfusion. Neuroscience Letters 287(2000)113~116
, 百拇医药
8 Shibata S、 Tominaga K、 Watanabe S. Kappa-Opioid receptor agonist protects against ischemic reduction of 2-deoxyglucose uptake in morphine-tolerant rats.Eur J Pharmacol,1995 Jun 12;279(2~3):197~202
9 黎沾良主编.现代危重病学.安徽科学技术出版社，1998：114~115
10 Minghetti L.and Levi G.Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide.Prog.Neurobiol, 1998, 54:99~125
11 Liu B、 Du L、 Kong LY、 et al.Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron-glia co-cultures. Neuroscience，2000.97(4):749~56
, 百拇医药
12 Liu B、Du L、Hong JS.Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation.J Pharmacol Exp Ther,2000 May;293(2):607~617
13 Vink R、 McIntosh TK、 Demediuk P、 et al.Decline in intracellular free Mg is associated with irreversible tissue injury after brain trauma.J Bio Chem, 1988, 263:757~759
14 Heath DL, Vink R.Traumatic brain axonal injury produces sustained decline in intracellular free magnesium concentration. Brain Res, 1996, 738:150~153
, 百拇医药
15 Vink R、 McIntosh TK、 et al.Opiate antagonist nalmefene improves intracellular free Mg2+, bioenergetic state, and neurologic outcome following traumatic brain injury in rats.J Neurosci,1990 Nov;10(11):3524~3530
16 张光霁、朱诚、江基尧等.颅脑损伤后β-内啡肽的变化. 中华创伤杂志，1997，13：1(增刊)：24~26
17 朱诚、江基尧、陈长策等.急性颅脑损伤后各脑区和血浆中β-ELI含量变化的实验研究. 中华医学杂志，1989，69：343~346
18 McIntosh TK、 Vink R、 Yamakami I、 et al.Magnesium protects against neurological deficit after brain injury.Brain Res, 1989, 482:252~260
, 百拇医药
19 McIntosh TK、 Head VA、 Faden AI. Alterations in regional concentrations of endogenous opioids following traumatic brain injury in the cat.Brain Res, 1987, 10:425:225~233
20 Young RS、Hessert TR、 Pritchard GA、 et al. Naloxone exacerbates hypoxic-ischemic brain injury in the neonatal rat.Am J Obstet Gynecol, 1984, 150:52~56
21 Chang RC、 Rota C、 Glover RE、 et al. A novel effect of an opiod receptor antagonist, naloxone, on the production of reactive oxygen species by microglia: a study by electron paramagnetic resonance spectroscopy. Brain Res, 2000, 31: 224~229
, 百拇医药
22 Hayes RL、 Lyeth BG、 Jenkins LW、 et al. Possible effect of endogenous opiods in traumatic brain injury.J Neurosurg, 1990, 72:252~261
23 Flamm E、 Young W、Collins W、 et al.A phase I trial of naloxone treatment in acute spinal cord injury.J Neurosurg, 1985, 63:390~397
作者单位：157011 黑龙江省牡丹江市第二人民医院药剂科1
157000 黑龙江省牡丹江市第二人民医院脑科医院2, 百拇医药(付艳秋 白雪峰)
3 Tymianski M、Tator CH.Normal and abnormal calcium homeostasis in neurons: a basis for the pathophysiology of traumatic and ischemic central nervous system injury. Neurosurg, 1996, 38:1176~1195
4 Fade AI、Demediuk P、Panter SS、et al. The role of ecitatory amino acids and NMDA receotors in traumatic head injury.Science, 1989, 244:798~800
, http://www.100md.com
5 Rysard Przewlocki et al.Opioid Enhancement of Calcium Oscillations and Burst Events Involving NMDA Receptors and L-Type Calcium Channels in Cultured Hippocampal Neurons.The Journal of Neuroscience, 1999, 19(22): 9705~9715
6 JC Yang、J Shan、 et al.Morphine and methadone have different effect on calcium channel currents in neuroblastoma cells.Brain Research, 2000, 870:199~203
7 Chun-Jung Chen、 Fu-Chou Cheng、 et al.Effects of naloxone on lactate, pyruvate metabolism and antioxidant enzyme activity in rat cerebral ischemia/reperfusion. Neuroscience Letters 287(2000)113~116
, 百拇医药
8 Shibata S、 Tominaga K、 Watanabe S. Kappa-Opioid receptor agonist protects against ischemic reduction of 2-deoxyglucose uptake in morphine-tolerant rats.Eur J Pharmacol,1995 Jun 12;279(2~3):197~202
9 黎沾良主编.现代危重病学.安徽科学技术出版社，1998：114~115
10 Minghetti L.and Levi G.Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide.Prog.Neurobiol, 1998, 54:99~125
11 Liu B、 Du L、 Kong LY、 et al.Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron-glia co-cultures. Neuroscience，2000.97(4):749~56
, 百拇医药
12 Liu B、Du L、Hong JS.Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation.J Pharmacol Exp Ther,2000 May;293(2):607~617
13 Vink R、 McIntosh TK、 Demediuk P、 et al.Decline in intracellular free Mg is associated with irreversible tissue injury after brain trauma.J Bio Chem, 1988, 263:757~759
14 Heath DL, Vink R.Traumatic brain axonal injury produces sustained decline in intracellular free magnesium concentration. Brain Res, 1996, 738:150~153
, 百拇医药
15 Vink R、 McIntosh TK、 et al.Opiate antagonist nalmefene improves intracellular free Mg2+, bioenergetic state, and neurologic outcome following traumatic brain injury in rats.J Neurosci,1990 Nov;10(11):3524~3530
16 张光霁、朱诚、江基尧等.颅脑损伤后β-内啡肽的变化. 中华创伤杂志，1997，13：1(增刊)：24~26
17 朱诚、江基尧、陈长策等.急性颅脑损伤后各脑区和血浆中β-ELI含量变化的实验研究. 中华医学杂志，1989，69：343~346
18 McIntosh TK、 Vink R、 Yamakami I、 et al.Magnesium protects against neurological deficit after brain injury.Brain Res, 1989, 482:252~260
, 百拇医药
19 McIntosh TK、 Head VA、 Faden AI. Alterations in regional concentrations of endogenous opioids following traumatic brain injury in the cat.Brain Res, 1987, 10:425:225~233
20 Young RS、Hessert TR、 Pritchard GA、 et al. Naloxone exacerbates hypoxic-ischemic brain injury in the neonatal rat.Am J Obstet Gynecol, 1984, 150:52~56
21 Chang RC、 Rota C、 Glover RE、 et al. A novel effect of an opiod receptor antagonist, naloxone, on the production of reactive oxygen species by microglia: a study by electron paramagnetic resonance spectroscopy. Brain Res, 2000, 31: 224~229
, 百拇医药
22 Hayes RL、 Lyeth BG、 Jenkins LW、 et al. Possible effect of endogenous opiods in traumatic brain injury.J Neurosurg, 1990, 72:252~261
23 Flamm E、 Young W、Collins W、 et al.A phase I trial of naloxone treatment in acute spinal cord injury.J Neurosurg, 1985, 63:390~397
作者单位：157011 黑龙江省牡丹江市第二人民医院药剂科1
157000 黑龙江省牡丹江市第二人民医院脑科医院2, 百拇医药(付艳秋 白雪峰)