摘要：多药耐药(multidrug resistence，MDR)是肿瘤化疗失败的主要原因，多年来学者一直致力于多药耐药机制的研究。神经酰胺作为细胞凋亡的第二信使，参与多种细胞凋亡，它与凋亡相关因子bcl-2、NF-κB的关系一直是研究的重点。葡萄糖神经酰胺合成酶(glucosylceramide synthase，GCS)可催化神经酰胺糖基化使其转变为葡萄糖神经酰胺，许多研究证明GCS与MDR表型有关。

    关键词：多药抗药性；神经酰胺；bcl-2；NF-κB；葡糖神经酰胺合酶

    中图分类号： R730.2文献标识码：A文章编号：1672-979X(2007)05-46-04

    Ceramide Metabolism and Its Relationship with Multidrug Resistance of Tumors

    HU Ping-ping, TIAN Bo, CHEN Tong-yu

    (Department of Pathology, the Third Affiliated Hospital of Suzhou University, Changzhou 213003, China)

    Abstract：Multidrug resistance is considered to be the main obstacle to the effective chemotherapeutics, which has been investigated for years in the medical field. Ceramide functions as a second messenger to several signaling pathways, and the relationship between it and bcl-2 or NF-κB has always been emphasized. Glucosylceramide synthase(GCS)catalyzes the glycosylation and inactivation of ceramide to glucosylceramide, which has been proved to be responsible for MDR phenotype. ......