α-亚麻酸多重乳液的稳定性研究
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摘要：目的制备较为稳定的α-亚麻酸多重乳液。方法以多重乳液相对体积为衡量标准，用显微镜直接观察，分别探讨第一相中复合乳化剂亲水-亲油平衡(HLB)值以及复合乳化剂质量分数对α-亚麻酸W/O/W多重乳液稳定性的影响。用紫外分光光度法测定α-亚麻酸在多重乳液中的稳定性。结果第一相复合乳化剂HLB值为6.6，M(复合乳化剂)∶M(EL35)=5.6，乳化剂在多重乳液中的质量分数为9.9 %时，多重乳液相对体积最大，α-亚麻酸在多重乳液中的稳定性最好。结论制备了较稳定的α-亚麻酸多重乳液。
关键词：α-亚麻酸；多重乳液；稳定性
中图分类号：Ts218文献标识码：A文章编号：1672-979X(2009)01-0036-03
Study on Stability of α-Linolenic Acid Multiple Emulsion
ZHANG Shi-xian1, 2, ZHONG Rui-qiang1, LIU Feng1, WANG Zheng-wu1 *, WANG Zhong-ni3
(1. School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China; 2. Chemistry Department; Zunyi Normal College; Zunyi 563002, China; 3. College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China)
Abstract：Objective To prepare stable α-linolenic acid multiple emulsion. Methods With relative volume percentages as measurement data, the effects of HLB value and concentration of complex emulsifier in the first phase on the stability of α-linolenic acid multiple emulsion (W/O/W) were examined by microscopic observation. The stability of α-linolenic acid in multiple emulsion was measured by ultraviolet spectrophotometry. Results The optimum conditions for complex emulsifier system were as follows: the HLB value of complex emulsifier in the first phase was 6.6; the ratio of M (complex emulsifier) to M (EL35) was 5.6; the mass fraction of emulsifiers in multiple emulsion was 9.9 %. Under the conditions mentioned above, the relative volume percentage of multiple emulsion was the biggest and the stability of α-linolenic acid was the best. Conclusion α-Linolenic acid multiple emulsion can be prepared with better stability.
Key words：α-linolenic acid; multiple emulsion; stability
α-亚麻酸(α-LNA)为全顺式9, 12, 15-十八碳三烯酸，属ψ-3系列多不饱和脂肪酸，结构式见图1。药理实验表明，α-LNA在降血脂[1]、抗血栓[2]、抗炎、抗过敏[3]、预防心脑血管疾病[4,5]等方面都起着重要作用。人体内不能产生α-LNA，只能从外源食物中摄取。通过去饱和酶和碳链延长酶的催化作用，α-LNA可在体内代谢为二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)。因此，α-LNA是重要的保健食品原料。
图1α-LNA分子结构式
多重乳液是一种水包油型和油包水型乳液共存(W/O/W)的复杂体系，是乳液中的乳液。多重乳液有许多特点，如三相共存且互不作用、缓释功能、包裹作用等，已广泛用于日用化工、食品、医药等行业[6]。但由于多重乳液为热力学不稳定体系，易分层，因此，制备稳定的多重乳液是将其投入生产前的必经过程 ......
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