尿中盐酸曲马多的快速分析方法(1)
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[摘要]目的：通过考察尿中盐酸曲马多及其代谢物的提取方法，建立其气相色谱-质谱(GC-MS)的检测方法。方法：采用C18固相萃取法对尿中曲马多原体及其主要代谢物进行提取，利用GC-MS对其进行检测。结果：线性范围为0.1~100μg/ml(r=0.9957，n=6)，平均回收率为99.21%，相对标准偏差为2.83%，最低测量限为 0.1 g/ml 。结论：本实验研究建立了尿中曲马多及其代谢物的快速、简便、准确、灵敏的检测方法，可作为快速检测吸毒人员尿中是否含有曲马多的一种有效的方法。
[关键词]曲马多；代谢物；气相-质谱法；固相萃取
[中图分类号]O657[文献标识码]A [文章编号]1673-7210(2007)05(b)-009-03
The rapid analysis method of tramadol hydrothloride injection in urine
JIANG Wei
(Shengjing Hospital,Affiliated Hospital of China Medical University,Shenyang 110004,China)
[Abstract] Objective：To examine the optimal extractive conditions of tramadol and its metabolite from urine and establish a detection method of tramadol by GC-MS. Methods：A solid-phase extraction and gas chromatography-mass spectrometry(SPE-GC-MS) procedure for the simultaneous detection of tramadol and its main metabolite in urine has been developed ......
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