丹栀逍遥散胶囊对慢性应激抑郁模型下丘脑单胺类神经递质的影响(2)
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本研究显示：丹栀逍遥散胶囊高剂量组大鼠下丘脑内5-HT含量增加，而5-HIAA含量降低，与模型组比较差异明显(P0.05)，提示丹栀逍遥散胶囊在提高5-HT含量的功能上与氟西汀组无明显差异，因此可推断丹栀逍遥散胶囊治疗抑郁症的作用部位可能在下丘脑，通过调节5-HT及其代谢产物5-HIAA、DA及其代谢产物DOPAC而发挥作用，一方面增加下丘脑内5-HT、DA含量，一方面减低下丘脑内5-HT代谢产物5-HIAA而改善抑郁症状，达到治疗目的。
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(收稿日期：2007-08-14)
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