高效液相色谱法测定雷贝拉唑钠血药浓度
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[摘要] 目的：建立测定雷贝拉唑钠血药浓度的高效液相色谱法。方法：采用Hypersil C18柱(4.6 mm×200 mm，5 μm)，以乙腈-水(32∶68)为流动相，流速1.0 ml/min，检测波长288 nm。结果：本方法线性范围5~1 600 μg/L，r=0.999 3，回收率为95.48%~99.13%。日内及日间RSD均小于4%。结论：本方法灵敏、准确、重现性好，适用于雷贝拉唑钠药代动力学研究。
[关键词] 雷贝拉唑钠；血药浓度；高效液相色谱法
[中图分类号]R917 [文献标识码]A [文章编号]1673-7210(2008)01(c)-029-02
Determination of rabeprazole sodium in serum by HPLC
GUO Li-min1, ZHONG Shi-hua2*
(1.Pharmacy of Yiyang City Central Hospital in Hunan Province, Yiyang 413000, China;2.Chemical Engineering College of Hunan Normal University, Changsha 410081,China)
[Abstract] Objective：To set up a reverse phase HPLC method for determining the concentration of rabeprazole sodium in serum in order to study its clinical pharmacokinetics.Methods：The chromatographic separation was carried out on Hypersil C18 column(4.6 mm×200 mm,5 μm), the mobile phase was acetonitrile-water(32∶68) and flow rate was 1 ......
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