溴氰菊酯对大鼠脑血红素氧化酶-1的影响(1)
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[摘要] 目的：研究溴氰菊酯(DM)对大鼠脑皮质及海马血红素氧化酶-1(HO-1)mRNA及蛋白表达的影响。方法：健康SD雄性大鼠36只，随机分为对照组(腹腔注射色拉油)、低剂量DM组(腹腔注射1.25 mg/kg DM)、高剂量DM组(腹腔注射12.5 mg/kg DM)，连续染毒5 d，末次染毒24 h后以原位杂交法测定皮质及海马HO-1 mRNA的表达，以免疫组化法测定HO-1蛋白表达。结果：与正常对照组相比，高剂量DM组HO-1 mRNA表达阳性细胞数明显增多(P<0.05)；而HO-1蛋白表达阳性细胞数则在低剂量DM组、高剂量DM组大鼠均明显增高(P<0.05)，并随着染毒剂量的增加表达明显增强(P<0.05)。结论：溴氰菊酯可诱导大鼠脑皮质及海马HO-1表达增加，发挥一定保护作用。
[关键词] 溴氰菊酯；血红素氧化酶-1；大鼠
[中图分类号] R91 [文献标识码]B [文章编号]1673-7210(2008)03(c)-024-02
The effects of deltamethrin on heme oxygenase-1 in rats
LIU Yu-mei，WU Ling，WANG Ji-hong，YI Cong
(Department of Preventive Medicine, Hainan Medical College, Haikou 571101,China)
[Abstract] Objective: To observe the expression changes of heme oxygenase-1(HO-1) and its mRNA induced by delmathrin(DM) in rats. Methods: 36 healthy male SD rats were randomly divided into control, low DM(1.25 mg/kg DM), high DM(12.5 mg/kg DM)exposed groups, by giving intraperitoneal injection for 5 days. The number of protein expression of hemeoxygenase-1 and its mRNA were detected at 24 hours after the last intraperitoneal administration.Results: The HO-1 and its mRNA expressed positive cells were significantly increased in high DM group (P
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