348例次癫痫儿童丙戊酸血药浓度回顾性分析(1)
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[摘要] 目的:为癫痫儿童丙戊酸钠的合理用药提供参考。方法:采用程序升温气相色谱法对348例次癫痫儿童服用丙戊酸钠进行血药浓度监测,并对血药浓度结果与剂型、合并用药、临床疗效的关系进行分析总结。结果:使用丙戊酸钠缓释片的癫痫患儿其血药浓度偏高;卡马西平可使丙戊酸的血药浓度降低;丙戊酸有效血药浓度的范围较大。结论:丙戊酸血药浓度监测对癫痫儿童合理用药有重要的指导作用,血药浓度个体差异较大,临床用药时需个体化给药。
[关键词] 程序升温气相色谱法;丙戊酸;血药浓度监测
[中图分类号] R742.1[文献标识码]C [文章编号]1673-7210(2008)08(b)-064-03
Retrospective analysisof serum concentrations of valproic acid of 348 epileptic children
ZHOU Jun, MEI Yan, SONG Xin-wen
(Children's Hospital of Wuhan,Hubei Province,Wuhan430016,China)
[Abstract] Objective: To give some information about rationally administrating valproic acid for epileptic children. Methods:Concentrations of valproic acid in serum of 348 epileptic children were detected by capillary colum gas chromatography with a rising column temperature program,and analyzed the relationships of serum concentration with dose types,clinical effects and the combination medication ......
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