黑桑椹对老年大鼠的活血降脂作用研究(1)
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[摘要] 目的：研究黑桑椹对老年大鼠的活血降脂作用。方法：老年大鼠被随机分为对照组、10%果汁组、10%桑椹果组3组，8周后，大鼠的血清和血液用于各项指标的。结果：与对照组相比，黑桑椹果汁和桑椹果组大鼠的红细胞超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、膜结合酶(Na+-K+-ATP酶)活性，以及高密度脂蛋白含量均增加；膜脂流动性得到改善；同时，桑椹组的血清和红细胞膜中脂质过氧化产物丙二醛(MDA)含量和血液总胆固醇含量降低；处理组抗动脉硬化指数与对照组相比显著升高(P<0.05)。结论：黑桑椹果与果汁具有一定的活血、降脂和抗动脉粥样硬化的效果。
[关键词] 黑桑椹；降脂；活血；大鼠
[中图分类号] R965[文献标识码]A [文章编号]1673-7210(2009)01(a)-009-03
Study on activating blood and hypolipidemic effects of black mulberry on aged rats
YUAN Bao-hong1, HU Li-yong1, DU Ping-xia2
( 1.Microbiology and Immunology Staff Room of Basic College, Guangdong pharmaceutical University, Guangzhou 510006, China； 2.Institute for Applied Technology of Computer，Guangdong Vocational College of Science and Trade, Guangzhou 510640, China)
[Abstract] Objective: To study the activating blood and hypolipidemic effects of black mulberry on aged rats. Methods:Aged rats were randomly divided into 3 groups. Treatment rats were fed with black mulberry fruits or juice, respectively. The blood of rats in treatment groups and control group was determined after 8 weeks treatment. Results: Compared to the control group, SOD, GSH-Px, the primary enzyme of the membrane Na+-K+-ATPase activities of rat erythrocytes and HDL-C in the blood treated by mulberry juice and fruits were increased, and the erythrocyte membrane fluidity of aged rats were improved; at same time, mulberry treatment significantly decreased MDA content in the serum and erythrocytes total cholesterol(TC) of rats. The anti-atherogenic indexes (AAI) were distinguished increased in the mulberry groups(P<0.05). Conclusion: Black mulberry fruits and juice have effects on activating blood, hypolipidemic and anti-atherosolerosis effects.
[Key words] Black mulberry; Hypolipidemic effects; Activating blood; Rats
桑椹是一种桑科植物桑 (Morus alba L. )的果实，桑在世界各地分布广泛，在热带、亚热带和温带气候环境中均有生长[1]。中国有6 000多年的栽桑养蚕历史，桑椹资源十分丰富。桑的叶、果、木和根有很多用途。历代草本将其列为滋阴补肾、黑发明目的滋补抗老药材。《本草纲目》对其食疗价值记载：味甘、辛、寒、无毒、利肝养肾。研究报道桑叶抽提成分能显著降低糖尿病小鼠的胆固醇[2]、血糖水平[3]、植物激素[4]和糖蛋白[5]；黑桑椹具有调节促进免疫功能，延长果蝇寿命，抗诱变等作用且无毒性[6,7] ......
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