蒙药那如-3治疗交通事故性脊髓损伤患者66例疗效观察(1)
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[摘要] 目的：观察交通事故性脊髓损伤患者用蒙药那如-3治疗66例的疗效。方法：在我院手术治疗的交通事故性脊髓损伤截瘫患者66例，随机分为常规治疗组(A组)和常规治疗加蒙药那如-3治疗组(B组)，每组33例。A组术后常规营养神经治疗；B组术后常规营养神经治疗的同时加蒙药那如-3治疗。治疗前、治疗2周后两组患者进行ASIA评分标准评定、脊髓减压改善率及检测血SOD、LPO、EGF的变化。结果：治疗2周后，B组患者损伤脊髓减压改善率、ASIA评分得分及SOD、EGF、LPO等指标明显优于A组，两组间比较差异有统计学意义(P<0.05)。结论：交通事故性脊髓损伤后手术及营养神经治疗并联合蒙药那如-3治疗效果好。
[关键词] 交通事故性脊髓损伤；蒙药那如-3；疗效观察
[中图分类号] R744 [文献标识码]B [文章编号]1673-7210(2009)01(c)-045-02
Effects of therapy of Mongaolian medicine Naru-3 on traffic accident of spinal cord injury
BULIN Bai-yi-la1，LUO Li-min1，CHEN Ji-ming2，SONG Xiao-xiong2
(1.Nancun Hospital of Guangzhou Panyu District，Guangzhou511442, China; 2. Department of Orthopaedics, Affiliated Hospital of Guangdong Medical College, Zhanjiang524001, China)
[Abstract] Objective: To observe the effects of Mongaolian medicine Naru-3 on traffic accident of spinal cord injury (SCI). Methods: After operation of 66 cases of spinal cord injury patients were randomly divided into two groups. Each group was 33 cases. Group A was normal treated after operation and group B was normal treated and treated with Mongaolian medicine Naru-3 after operation .The ASIA scale and the rate of spinal cord reduced pressure was employed to assess and SOD, LPO, EGF changes were determined in the patients before and after treatment for 4 weeks in the two groups. Results: After 4 weeks of therapy ASIA scores and rate of spinal cord reduced pressure and SOD, LPO, EGF changed in the B group were better than those of A groups. there was significant differences between the 2 groups (P<0.05 ). Conclusion: The Mongaolian medicine Naru-3 is more effective in traffic accident of spinal cord injury.
[Key words] Traffic accident of spinal cord injury; Mongaolian medicine Naru-3; Therapy
随着交通业的高速发展，脊髓损伤的发生率不断上升，脊髓损伤(Spinal cord injury，SCI)的治疗一直没有突破。最近研究发现，蒙药那如-3对脑损伤后神经细胞有保护作用[1]。本研究观察蒙药那如-3治疗对交通损伤性脊髓损伤患者功能修复的效果。
1对象与方法
1.1研究对象
2007年10月～2008年8月，在我院手术治疗的交通损伤性脊髓损伤致截瘫患者66例，男42例，女24例；年龄16～67岁，平均36.8岁；均在外伤后截瘫，X线片、CT或MRI及手术证实，胸腰椎骨折合并脊髓压迫伤或脊髓挫伤。随机分为常规治疗组(A组)和常规治疗加蒙药那如-3治疗组(B组)，每组33例。两组之间年龄、性别、损伤程度比较，差异无统计学意义。
1.2研究方法
A组术后常规营养神经治疗；B组术后常规营养神经治疗的同时蒙药那如-3治疗(内蒙古乌兰浩特蒙药制药厂生产)，1 g/次，1 次/d，共2周。
1.3疗效评定方法
对两组患者治疗前和治疗2周后采用ASIA(American Spinal Cord Injury Association， International standards for neurological and functional classification of spinal cord injury)进行评分[2]和检测治疗前后损伤脊髓减压改善率；同样治疗前、治疗后2周，对患者血超氧化物歧化酶(SOD)、表皮细胞因子(EGF)、脂质过氧化物(LPO)进行检测。
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