胃癌组织Survivin、COX-2、Ki67的表达及意义
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[摘要] 目的：探讨胃癌组织中凋亡抑制蛋白(Survivin)、环氧合酶-2(COX-2)及核增殖抗原(Ki67)的表达与生物学特性的关系。方法：采用免疫组织化学染色(S-P)法检测58例胃癌标本Survivin、COX-2及Ki67的表达，并以58例正常胃黏膜作为对照组。结果：胃癌组织中Survivin及COX-2表达率分别为79.31%和82.76%，均高于正常胃黏膜(P<0.01)；Survivin及COX-2的表达与胃癌性别、年龄、部位及大小无相关性(P>0.05)，而与胃癌的浸润深度、淋巴结转移及TNM分期有关(P<0.05)，且二者有相关性(P<0.05，r=0.443)。Survivin及COX-2表达阳性组与阴性组比较，Ki67的表达差异有统计学意义(P<0.01)。结论：Survivin、COX-2及Ki67在胃癌的发生、发展中起着重要作用，可作为反映胃癌生物学行为的指标。
[关键词] 胃癌；Survivin；COX-2；Ki67；免疫组织化学染色
[中图分类号] R735.2[文献标识码]A [文章编号]1673-7210(2009)02(a)-017-03
The clinical significance and expression of Survivin, COX-2 and Ki67 in gastric carcinoma
HAO Wang-sheng, ZHANG Dong, HOU Pei-zhen
(The First Affiliated Hospital of Baotou Medical College, Baotou014010, China)
[Abstract] Objective: To explore the expression of Survivin, COX-2 and Ki67 in gastric carcinoma and their relationship with biological characteristics. Methods: The expression of Survivin, COX-2 and Ki67 in the tumor tissues from 58 cases of gastric carcinoma was examined by immunohistochemical S-P method，and 58 cases of normal gastric mucosa served as control group. Results: The positive rates of Survivin and COX-2 were 79.31% and 82.76% respectively, higher than those of the control group (P<0.01). The expressions of Survivin and COX-2 were not associated with sex, age, location and size of gastric cancer (P>0.05), but were correlated with the depth of tumor infiltration (P<0.05), and the extent of lymph node metastasis (P<0.05) and TNM stage of cancer (P<0.05). The expressions of Survivin and COX-2 had correlation in gastric carcinoma (P<0.05, r=0.443). Ki67 expression had statistical significance between Survivin and COX-2 positive expression group and negative expression group (P<0.01). Conclusion: Our results suggested that Survivin, COX-2 and Ki67 play an important role in the genesis and development of gastric carcinoma, which could be the index of prognostic evaluation and determination of gastric carcinoma biological behavior.
[Key words] Gastric cancer; Survivin; COX-2; Ki67; Immunohistochemistry ......
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