兰索拉唑对大鼠乙醇急性胃病变保护作用的研究(1)
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[摘要] 目的：观察兰索拉唑对大鼠乙醇性急性胃病变保护作用的影响。方法：将大鼠随机分为正常对照组、模型对照组、兰索拉唑组和奥美拉唑组，采用无水乙醇诱导大鼠急性胃黏膜损伤，分别测定胃黏膜血流量(GMBF)、跨膜电位(PD)、胃黏膜损伤指数(UI)、前列腺素E2(PGE2)和血栓素B2(TXB2)，并在光镜下观察胃黏膜的病理学改变。结果：与模型对照组比较，兰索拉唑组大鼠UI明显降低(P<0.01)，GMBF值增加，PD值明显增加，胃黏膜内源性PGE2含量增加，TXB2含量降低。结论：兰索拉唑对大鼠胃黏膜具有重要的保护作用，增加胃黏膜血流量，并与PGE2合成有关。
[关键词] 兰索拉唑；胃黏膜损伤；胃黏膜血流量；前列腺素
[中图分类号]R573 [文献标识码]A [文章编号]1673-7210(2009)03(a)-012-03
Study of protection of Lansoprazole to acute injury of gastric mucosal lesion in rats caused by alcohol
CAI Xue-tao, YANG An-ping, FENG Wei
(1.The First People's Hospital of Foshan, Foshan528000, China; 2.Foshan Science Technical College, Foshan528000, China; 3.Songgang Hospital of Nanhai, Foshan City, Foshan528234, China)
[Abstract] Objective: To investigate the protection of Lansoprazole to acute injury of gastric mucosal lesion in rats caused by alcohol. Methods: Rats were randomly divided into normal control group, model control group, Lansoprazole group and Omeprazole group, acute injury of gastric mucosal lesion in rata was caused by absolute alcohol, gastric mucosal blood flow (GMBF), transmembrane potential (PD), gastric mucosal damage index(UI), prostaglandin E2 and thromboxan B2 were measured, pathological change was observed by light microscope. Results: GMBF, PD and PGE2 in Lansoprazole group were higher than those in model control group, UI and thromboxan B2 in Lansoprazole group were lower than those in model control group(P<0.01). Conclusion: Lansoprazole may have great protection to gastric mucosa of rats, it may increase gastric mucosal blood flow by promoting the synthesis of PGE2.
[Key words] Lansoprazole; Gastric mucosal damage; Gastric mucosal blood flow; Prostaglandin
兰索拉唑为苯咪唑类药物，可选择性阻断H+/K+-ATP酶而抑制胃酸的分泌。Coruzzi G等[1]报道，兰索拉唑口服给药对慢性胃炎及十二指肠溃疡的愈合有显著的促进作用。邵润轩等[2]对无水乙醇引起大鼠急性胃黏膜损伤的机制研究表明，GMBF在胃黏膜的防御中起重要作用，PGE2也是胃黏膜细胞保护作用的主要因子。为了进一步证实其对胃黏膜保护的药理作用及相互关系，本实验应用兰索拉唑治疗乙醇诱导大鼠胃黏膜急性胃病变并测定多项实验指标，报道如下：
1 材料与方法
1 实验材料
1.1.1 实验动物健康SD大鼠，雄性，体重(180±20) g，由广东省岭南实验动物厂提供。
1.1.2 实验试剂兰索拉唑片(30 mg，汕头经济特区鱼它滨制药厂，批号：080602)，奥美拉唑肠溶胶囊(20 mg，海南海口奇力制药公司，批号：070501) ......
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