彩超对山莨菪碱联合肝素股动脉注射治疗糖尿病下肢血管病变的疗效评价(1)
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[摘要] 目的：探讨山莨菪碱、肝素联合股动脉注射治疗早期糖尿病下肢血管病变的疗效。方法：80例经彩色多普勒检查诊断为糖尿病下肢血管病变的糖尿病患者，给予山莨菪碱10 mg、肝素50 mg加生理盐水5 ml股动脉注射，每天1次，10次为1个疗程后，再予以彩色多普勒复查，对治疗前后超声数据进行统计分析。结果：治疗后患者下肢麻木、疼痛及足凉等症状减轻或消失，彩色多普勒复查显示血流动力学指标明显改善，下肢动脉的内径增宽、频谱变窄及加速度/减速度比值减小(P<0.01)。结论：山莨菪碱、肝素联合股动脉注射治疗糖尿病下肢血管病变疗效确切、安全、经济、实用，无明显毒副作用，值得推广应用。
[关键词] 彩色多普勒；山莨菪碱；肝素；治疗；糖尿病下肢血管病变
[中图分类号] R587.2[文献标识码]A [文章编号]1673-7210(2009)03(b)-014-03
Color Doppler ultrasonographic estimating therapy of early diabetic lower extremity arterial disease of diabetic patient by femoral artery injection of Anisodamine and Heparin
ZHU Haiyan
(The Affiliated Hospital of Shandong Medical College, Linyi276004, China)
[Abstract] Objective: To investigate the curative effect of femoral artery injection combined with Anisodamine and Heparin on the treatment of early diabetic lower extremity arterial disease. Methods: 80 diabetic patients diagnosed with lower extremity arterial disease by color Doppler were treated with 10 mg Anisodamine and 50 mg Heparin and 5 ml normal saline for femoral injection every day for 10 days. It was re-examined by color Doppler, and statistical analysis was carried out for the data before and after treatment. Results: The numbness, pain and leg cold and so on were obviously relieved or disappeared. Doppler showed that the hemodynamic was significant improved. The diameter of the vessels increased, the spectrum narrowed, the ratio of acceleration/deceleration decreased. Conclusion: Femoral injection with Anisodamine and Heparin is firmly effective, safe, cost-effective and applied for lower extremity arterial disease of diabetic patient, no obvious cruel side effect, and is worthy of popularity and utilization.
[Key words] Color Doppler; Anisodamine; Heparin; Treatment; Lower extremity arterial disease of diabetic patient
糖尿病是影响人民身体健康的常见病，随着糖尿病患者生存时间逐年延长，慢性并发症越来越多见，其中以大血管病变占首位。糖尿病下肢血管病变(lower extremity arterial disease of diabetic patient, LEADDP)是糖尿病的常见并发症，是糖尿病患者致残的主要原因，严重威胁着糖尿病患者的生存质量和生存时间，因国内广大糖尿病患者生活并不富裕，故寻找治疗糖尿病下肢血管病变既经济实用又疗效可靠的治疗方案具有极其重要的意义。本文通过彩色多普勒对山莨菪碱、肝素联合股动脉注射治疗早期糖尿病下肢血管病变的疗效进行了观察和分析。
1 材料与方法
1.1 研究对象
根据1998年WHO的糖尿病诊断标准，确诊为2型糖尿病并经彩色多普勒诊断为糖尿病下肢血管病变的80例患者入选，其中，男性40例，女性40例。年龄52～74岁，平均62.9岁。病程6.5～21年，平均11.1年，给予口服降糖药或胰岛素治疗，使糖化血红蛋白(HbA1c)控制在7%左右，均排除血管栓塞、血管炎、血管畸形、贫血、慢性肺源性心脏病等疾病，均未用其他抗凝剂及血管扩张剂。
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