CEACAM6在卵巢癌中的表达及临床意义(1)
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[摘要] 目的：研究CEACAM6在卵巢癌中的表达及意义。方法：用免疫组化S-P法研究CEACAM6在20例卵巢癌手术切除标本及10例卵巢上皮良性肿瘤中的表达。结果：CEACAM6在卵巢癌中的表达率与在卵巢上皮良性肿瘤中的表达率有显著性差异(P<0.05)；CEACAM6在卵巢癌高、中、低分化组中都有阳性表达，组间比较无显著性差异(P>0.05)；CEACAM6在浆液性和黏液性囊腺癌中均有阳性表达，二者比较有显著性差异(P<0.05)；并在转移淋巴结中有阳性表达。结论：CEACAM6在卵巢癌及其转移淋巴结中有阳性表达，其表达率与卵巢癌的分化程度无显著相关，其在卵巢黏液性囊腺癌中的表达比浆液性囊腺癌中表达更强。
[关键词] CEACAM6；卵巢癌；免疫组化；PCNA；ki-67
[中图分类号] R73[文献标识码]A [文章编号]1673-7210(2009)03(c)-025-02
Expression and clinical significance of CEACAM6 in patients with ovarian cancer
CAI Yongjie, ZHAO Xingbo, LI Mingjiang, LI Jijun
(Shandong University Shandong Provincial Hospital, Ji'nan250021, China)
[Abstract] Objective: To study the expression and clinical significance of CEACAM6 in patients with ovarian cancer. Methods: The expression of CEACAM6 was determined in 20 cases of ovarian cancer and 10 cases of normal ovarian tissue with immunohistochemical S-P method. Results: A significant difference in the expression rate of CEACAM6 was shown betweenovarian cancer samples and normal ovarian tissue (P<0.05). The positive expression of CEACAM6 was observed in high, mediate and poor differentiated groups, and no significant difference was shown among groups (P>0.05); the positive expression of CEACAM6 was observed in both ovarian mucinous cystadenocarcinoma and ovarian serous cystadenocarcinoma, and a significant difference was shown between them (P<0.05), and it was also expressed in transferred lymph nodes. Conclusion: CEACAM6 is positively expressed in both ovarian cancer and its transferred lymph nodes, and its expression rate has no correlation with the differentiation degree of ovarian cancer, and it expresses stronger in ovarian mucinous cystadenocarcinoma than in ovarian serous cystadenocarcinoma.
[Key words] CEACAM6; Ovarian cancer; Immunohistochemistry; PCNA; ki-67
卵巢癌是妇女常见恶性肿瘤，发现时多为晚期，治愈率不到30%，死亡率高居妇科恶性肿瘤之首[1]，故研究卵巢癌的恶性生物学行为的早期诊断指标已成为新热点。本研究应用免疫组化S-P法检测PCNA、ki-67和CEACAM6三个指标在卵巢癌中的表达情况，讨论它们与卵巢癌恶性生物学行为的相关性，指导卵巢癌的诊断。
1 资料与方法
1.1 标本来源
收集2003年1月～2007年8月山东省立医院病理科卵巢癌患者标本20例 ......
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