自然周期IVF-ET 248例临床分析(1)
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[摘要] 目的：探讨自然周期体外受精-胚胎移植(NC-IVF-ET)技术在不孕症治疗中的临床应用价值。方法：采用SPSS统计软件包对248例行NC-IVF-ET和2 185例行控制性超排卵(短方案COH)助孕的患者促排卵结果进行分析。结果：NC-IVF-ET组的获卵率和临床妊娠率显著低于COH组(P<0.05)，周期取消率显著高于COH组(P<0.05)，但两组正常受精率、卵裂率和种植率均无显著性差异(P>0.05)。而NC-IVF-ET组的OHSS发生率和多胎妊娠率则显著低于COH组(P<0.05)。在各种原因引起的不孕症中，输卵管因素引起的不孕症临床妊娠率最高，而无获卵是最主要的取消原因。结论：NC-IVF-ET不使用促排卵药物，经济、安全，应在有适应证的不孕症患者中加以应用。
[关键词] 自然周期；体外受精-胚胎移植；不孕症
[中图分类号] R711.6[文献标识码]A [文章编号]1673-7210(2009)05(a)-045-03
Clinical analysis of 248 cases with natural cycle IVF-ET
TANG Li, MA Yanping, ZHANG Xiaomei, LI Yonggang, GAO Xianqiong
(Reproductive Department, the First People's Hospital of Yunnan Province, Kunming 650032, China)
[Abstract] Objective: To investigate the clinical value of natural cycle in vitro fertilization and embryo transfer (NC-IVF-ET) in the treatment of infertility. Methods: SPSS statistic software was used to analyze the clinical results of 248 patients received the treatment of the protocol of NC-IVF-ET and 2 185 patients received the treatment of controlled ovarian hyperstimulation (short protocol COH). Results: The rate of oocytes retrieved and the rate of clinical pregnancy of NC-IVF-ET group were significantly lower than that of COH group (P<0.05), and the cycle cancellation rate was significantly higher than that of COH group (P<0.05), but the normal rate of fertilization, merogenesis rate and planting rate showed no difference between the two groups (P>0.05). The rate of OSS and the multifetal pregnancy in NC-IVF-ET group were significantly lower than that of COH group (P<0.05). The rate of clinical pregnancy of the infertile couples which caused by ovarian duct obstruction was the highest, and no retrieved oocyte was the main reason of cycle cancelling. Conclusion: The protocol of NC-IVF-ET has the advantages of no need of ovarian stimulation medicine and is more economic and safe, it should be used in some patients who have indications.
[Key words] Natural cycle; In vitro fertilization and embryo transfer; Infertility
目前，许多生殖中心采用控制性超排卵(COH)的体外受精-胚胎移植(TVF-ET)技术治疗不孕症。但随着COH周期数的迅速增加，卵巢过度刺激综合征(OHSS)、多胎妊娠、早产、多余胚胎引发的伦理及宗教等问题日益引起社会的广泛关注；超生理剂量的激素使用更引发了对接受COH治疗妇女未来健康的担忧 ......
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