苦碟子注射液联合阿司匹林治疗脑梗死临床观察(1)
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[摘要] 目的：探讨苦碟子注射液联合阿司匹林治疗急性脑梗死的疗效。方法：112例脑梗死患者，随机分为治疗组(n=58)和对照组(n=54)，分别给予抗脑水肿药物和脑保护剂，同时口服阿司匹林；治疗组在此基础上加用苦碟子注射液。分别于治疗前、后评价两组患者神经功能缺损情况，比较病情程度。结果：两组患者在用药后第7、14、21、28天神经功能缺损评分和日常生活活动Barthel指数与前一观察日有显著性差异。与对照组比较，治疗组患者神经功能恢复早，在用药后第21、28天有显著性差异。两组用药后无明显不良反应。结论：苦碟子注射液联合阿司匹林治疗脑梗死疗效确切，安全性好。
[关键词] 脑梗死；苦碟子；阿司匹林
[中图分类号] R743.33[文献标识码]C [文章编号]1673-7210(2009)05(a)-076-02
Observation on combination of Kudiezi Injection and Aspirine therapy in treatment of patients with cerebral infarction
LI Yanqiu1, LIU Xuewen2
(1. Department of Internal Medical, the People's Hospital of Yixian, Jinzhou 121000, China; 2. Department of Neurology, the First Affiliated Hospital of Liaoning Medical College, Jinzhou 121001, China)
[Abstract] Objective: To evaluate efficacy of combination therapy of Kudiezi Injection and Aspirin in patients with acute stage cerebral infarction. Methods: The patients with cerebral infarction (n=112) were randomly divided into treatment group (n=56) and control group (n=54). Observation on clinical neurofunctional disorder and severity was carried out. Results: According to the Chinese Stroke Scale and the Barthel Score，we found that there were definite effectiveness and statistical significances in the patients of the two groups after the 7th，14th，21st，28th days of treatment comparing to those prior to the treatment.There were also significant differences between the above two groups regarding the efficacies of Kudiezi and Aspirine miltiorrhiza at the 21st and 28th days, of which the improvement of Chinese Stroke Scale and the Barthel Score came earlier and being more effective in the treatment group since the 2nd day. Adverse reactions were modest in all patients. Conclusion: Combination of Kudiezi Injection and Aspirine is effective and safe in treatment of cerebral infarction in acute stage.
[Key words] Cerebral infarction； Kudiezi Injection； Aspirine
急性脑梗死是我国中老年人的常见病、多发病，具有高致死率、高致残率的特点，严重威胁中老年人的身体健康，目前主张对脑梗死进行个体化治疗。我科应用苦碟子注射液联合阿司匹林治疗脑梗死，疗效好、安全性高，且无明显毒副作用，能扩张脑血管，增加脑血流量及提高抗血小板活化因子(PAF)的活性，降低血黏度，减少微血栓的形成 ......
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