口服伊曲康唑与氟康唑治疗念珠性阴道炎疗效比较
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[摘要]目的：评价伊曲康唑与氟康唑治疗念珠性阴道炎疗效。方法：采用单盲法随机分组，将129例念珠菌患者分为两组。伊曲康唑组65例，伊曲康唑200 mg/d，口服，连服3 d；氟康唑组64例，氟康唑150 mg/d，口服，连服3 d。结果：两组患者的指标无显著性差异，资料具有可比性，伊曲康唑组与氟康唑组治疗后的总有效率分别为95%(62/65)和94%(60/64)，两组比较无显著性差异(P>0.05)。不良反应发生情况为伊曲康唑组3例(5%)，氟康唑组2例(3%)，主要为胃肠道反应。结论：伊曲康唑与氟康唑治疗念珠性阴道炎的疗效、不良反应无显著性差异(P>0.05)。临床疗效确切，使用安全、方便。
[关键词] 伊曲康唑；氟康唑；念珠；阴道炎
[中图分类号] R711.3 [文献标识码]C[文章编号]1673-7210(2009)05(b)-153-02
Evaluating the efficacy of the treatments for beaded vaginitis between oral itraconazole andfluconazole
CHEN Yuhuang
(Huiyang Maternal and Child Health Hospital, Huizhou 516001,China)
[Abstract] Objective: To evaluate the efficacy of treatment for beaded vaginitis between itraconazole and fluconazole. Methods: The single-blind way with randomized groups was taken. 129 patients were divided into two groups: the itraconazole group, 65 cases, with 200 mg oral for 3 days. the fluconazole group, 64 cases, with 150 mg oral for 3 days. Results: there was no statistically significant difference between the indicators of two groups. The data was comp arable. The effective rates in itraconazole group and fluconazole group were respectively 95 percent (62/65) and 94 percent (60/64) (P>0.05).The incident rate of adverse reactions in itraconazole group was 5 percent (3 cases) and in fluconazole group was 3 percent (2 cases), mainly gastrointestinal reactions. Conclusion: There is no significant difference (P>0.05) in effectiveness and bad reactions in the treatments for beaded vaginitis bewteen itraconazole and fluconazole. The clinical effectiveness is definite, saft and convenient.
[Key words] Itraconazole; Fluconazole; Bead;Vaginitis
念珠菌性阴道炎由珠菌中的白色念珠菌感染所致，临床表现为外阴瘙痒、灼痛，白带呈白色稠厚豆腐样[1]。随着抗生素及糖皮质激素的广泛应用，发病率已逐年上升，目前已成为门诊较常见真菌感染性疾病之一。临床易复发是其治疗难点，口服治疗以伊曲康唑、氟康唑为主要药物，现比较2种抗真菌药物的临床疗效。
1 资料与方法
1.1病例选择
念珠菌患者129例，对唑类抗真菌药物都不过敏，无妊娠，无肝、肾疾病史。年龄10～46岁，病程2～15个月。采用完全随机分组单盲法将129例患者分为两组。其中，伊曲康唑组65例，男性23例，女性42例，年龄(34±10)岁，体重(62±8) kg，疗程(6.1±0.2) d，病程(1.10±0.15)年；氟康唑组64例，男性25例，女性39例，年龄(36±11)岁，体重(63±10) kg，疗程(4.0±1.4) d，病程(1.00±0.09)年。两组患者性别、年龄等差异无显著性(P>0.05)。
1.2 治疗方法
伊曲康唑组予伊曲康唑胶囊(成都倍特药业有限公司，批准文号：国药准字H20010767，规格100 mg) 200 mg/d，口服，连服3 d；氟康唑组予氟康唑山东方明药业股份有限公司，批准文号：国药准字H20046417，规格50 mg)150 mg/d，口服，连服3 d。停药7 d后复查临床症状及真菌镜检查真菌。
1.3观察项目
观察并逐项记录每例患者的症状、体征变化及与治疗目的无关的各种反应。
1.4 临床疗效评价标准
临床疗效评价标准按痊愈、显效、进步及无效4级评定，痊愈与显效合计为有效，并据此计算有效率。判断标准：痊愈为症状、体征，实验室检查均恢复正常；显效为病情明显好转 ......
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