联合检测CEA和CA199对结直肠癌的临床意义(1)
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[摘要] 目的:探讨单项及联合检测肿瘤标志物癌胚抗原(CEA)与糖类抗原199(CA199)在结直肠癌患者手术前后的表达及临床意义。方法:利用化学发光免疫方法检测70例结直肠癌患者术前及术后化疗3个月血清CEA和CA199水平,分析CEA和CA199检测值与结直肠癌的诊断及术后化疗临床特征之间的关系。结果:结直肠癌患者术前血清CEA和CA199水平显著高于术后化疗与健康对照组(P<0.05),手术后,经过3个月的化疗,结直肠癌患者的CEA和CA199水平与正常健康人无显著性差异(P>0.05),联合检测既可以提高对结直肠癌诊断的阳性率,又可以对术后化疗的效果进行评价。结论:血清CEA和CA199联合检测可用于结直肠癌的辅助诊断以及预后的判断。
[关键词] 结直肠癌;癌胚抗原;糖类抗原199
[中图分类号] R735.3+7[文献标识码]A [文章编号]1673-7210(2009)07(c)-014-02
Clinical significance of combined detection of CEA and CA199 in colorectal carcinoma
ZHONG Qifen, HUANG Zeqi
(The Second People's Hospital of Foshan, Foshan 528000, China)
[Abstract] Objective: To study the preoperative and postoperative expression and the clinical significance of carcinoembryonic antigen (CEA), carbohydrate antigen (CA199) and combined detection of colorectal carcinoma. Methods: The preoperative and 3 months postoperative changes of CEA and CA199 of 70 cases of patients with colorectal carcinoma were evaluated by chemiluminescence immunoassay, and the relationship between the diagnosis and postoperative chemotherapy clinical characteristics of colorectal carcinoma was analyzed. Results: The values of CEA and CA199 in patients with colorectal carcinoma in preoperation were higher than the patients underwent postoperative chemotherapy and the healthy individuals (P<0.05). After received chemotherapy for 3 months, the levels of CEA and CA199 of patients with colorectal carcinoma showed no difference compared with the healthy individuals (P>0.05). Combined detection could not only increased the positive diagnosis rate of colorectal carcinoma, but also appraised the postoperative chemotherapy effect. Conclusion: Combined detection of CEA and CA199 can be used in diagnosing and evaluating the prognosis of colorectal carcinoma.
[Key words] Colorectal carcinoma; CEA; CA199
结直肠癌作为常见的消化道恶性肿瘤之一,其发病率呈逐年上升的趋势,目前已居恶性肿瘤死亡率的第5位,其早期诊断对患者进行早期治疗、延长其寿命、提高生存质量有非常重要的意义;对结直肠癌进行术后化疗时,必须对患者进行监测,防止术中种植性转移和术后复发转移的发生。在结直肠癌的实验室诊断中,癌胚抗原(CEA)和糖类抗原199(CA199)是两种主要候选标志物,其单独检测在临床上已广泛应用。本研究旨在评估联合检测CEA和CA199在结直肠癌的诊断及术后化疗中的作用,以帮助临床工作者对结直肠癌进行准确的诊断和治疗。
1 资料与方法
1.1一般资料
2005年12月～2008年12月选择70例我院肛肠科手术治疗的结直肠癌患者,均经肠镜组织取材,活检,病理确认为癌,术后均在我院接受化疗,化疗标本采自接受化疗治疗3个月时 ......
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