HPLC法测定丙酸氯倍他索尿素乳膏中丙酸氯倍他索的含量(1)

http://www.100md.com 2009年8月5日 胡守莲　范玉峰

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     [摘要] 目的:建立丙酸氯倍他索尿素乳膏中丙酸氯倍他索含量的HPLC测定方法。方法:色谱柱为SHIMADZU VP-ODS C18柱(4.6 mm×150 mm,5 μm),流动相为0.05 mol/L磷酸氢二钠溶液(用85%磷酸溶液调节pH值至2.5)-乙腈-甲醇(42.5∶47.5∶10),流速为1.0 ml/min,检测波长为254 nm。结果:丙酸氯倍他索的线性范围为5～40 μg/ml,r=0.999 9,平均回收率为98.05%,RSD为0.72%。结论:本方法准确可靠、简单可行,可用于丙酸氯倍他索尿素乳膏中丙酸氯倍他索的含量测定。

    [关键词] 丙酸氯倍他索尿素乳膏;丙酸氯倍他索;高效液相色谱法;含量测定

    [中图分类号]R927.2 [文献标识码]A [文章编号]1673-7210(2009)08(a)-074-02

    Content determination of clobetasol propionate in Clobetasol Propionate Urea Cream by HPLC

    HU Shoulian1, FAN Yufeng2

    (1.Xinyang Institute for Food and Drug Control, He'nan Province, Xinyang464000, China; 2.Hospital Affiliated to Xinyang Vocational and Technical College, He'nan Province, Xinyang464000, China)

    [Abstract] Objective: To establish a HPLC method for the content determination of clobetasol propionate in Clobetasol Propionate Urea Cream ......

    http://www.100md.com/html/paper/1673-0089/2009/22/40.htm

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