甲硝唑口含片制备工艺研究
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[摘要] 目的:制备甲硝唑口含片。方法:以口感、外观、崩解时限、硬度、体外溶出度作为考察指标,采用正交试验设计法优化处方。结果:最佳处方:甲硝唑200 g、蔗糖粉40 g、甘露醇10 g、阿斯巴甜20 g、柠檬香精4%、羧甲基淀粉钠(CMS-Na)0.2%和硬脂酸镁0.5%。结论:该甲硝唑含片的制备工艺合理。
[关键词] 甲硝唑口含片;正交设计;溶出度
[中图分类号]R943 [文献标识码] A[文章编号] 1673-7210(2009)01(c)-058-02
Study on preparation of the Metronidazole Buccal Tablets
DU Liyue
(Luohe Medical College, Luohe 462002, China)
[Abstract] Objective: To prepare the metronidazole buccal Tablet. Methods: By using orthogonal design, different formula and active ingredients according to the characteristics of buccal tablets were evaluated by the effect of the taste, appearance characteristics, disintegrating time, hardness and in vitro dissolution ......
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