甘油单油酸酯液晶载体材料的体外毒性研究(1)
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[摘要] 目的:评价立方液晶载体材料甘油单油酸酯(glycerol monoolein,GMO)的细胞毒性。方法:体外培养大鼠皮肤成纤维细胞,以MTT法及琼脂覆盖法评价立方液晶对大鼠皮肤成纤维细胞的细胞毒性分级情况。结果:甘油单油酸酯对大鼠皮肤成纤维细胞的细胞活力无明显影响,毒性分级为0级。结论:甘油单油酸酯无潜在的细胞毒性,是一种生物相容性良好的载体材料。
[关键词] 立方液晶;甘油单油酸酯;细胞毒性
[中图分类号] R329.2+8[文献标识码]A[文章编号] 1673-7210(2010)04(a)-022-03
In vitro cytotoxic study on liquid crystalline material of glycerol monoolein
ZHOU Yanfang1, PENG Xinsheng2
(1.Department of Pathophysiology, Guangdong Medical College, Dongguan 523808, China; 2.Department of Pharmacy, Guangdong Medical College, Dongguan 523808, China)
[Abstract] Objective: To evaluate the cytotoxicity of glycerol monoolein (GMO). Methods: In vitro cultured rat skin flbroblast cells, MTT assay and agar overlay were used to evaluate toxicity grading of GMO on skin flbroblast cells ......
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