Bax和E2F-1在子宫腺肌病中的表达及意义(1)
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[摘要] 目的:研究在子宫腺肌病发生过程中凋亡调节蛋白Bax及转录因子E2F-1的病理生理作用。方法:运用免疫组化技术(SP法)检测子宫腺肌病组织(72例)和正常子宫内膜组织(55例)中Bax及E2F-1的表达情况。结果:Bax及E2F-1的表达在子宫腺肌病组织中均明显高于正常子宫内膜组织,两组比较,差异有统计学意义(P<0.05);而子宫腺肌病异位内膜组与原位内膜组比较,Bax及E2F-1的表达差异无统计学意义(P>0.05)。结论:Bax及E2F-1的持续表达与子宫腺肌病组织中异位内膜的过度增殖有关,提示其与子宫腺肌病的发生及发展有密切关系。
[关键词] Bax;E2F-1;子宫腺肌病
[中图分类号] R711.74 [文献标识码]B[文章编号]1673-7210(2010)04(a)-029-02
Expression and significance of Bax and E2F-1 in human adenomyosis
ZHANG Wei, AI Zhongwei, ZHENG Lihong, CHEN Ping, WANG Yu
(Pathology Center, Qiqihar Medical College, Qiqihar 161006, China)
[Abstract] Objective: To study the pathophysiological effect of expression of apoptosis regulating protein Bax and transcription factor E2F-1 in human adenomyosis. Methods: Immunohistochemical SP method was employed to detect the expression of Bax and E2F-1 in 72 specimens of eutopic endometrium of adenomyosis and 55 specimens of normal endometrium ......
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