利凡诺联合米非司酮与米索前列醇终止中期妊娠的临床疗效
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[摘要] 目的:探讨利凡诺联合米非司酮与米索前列醇终止中期妊娠的临床疗效。方法:选择2005年6月～2009年9月期间我站收治的要求终止妊娠的118例孕妇,随机分为观察组和对照组,每组59例。观察组采用利凡诺、米非司酮与米索前列醇联合治疗,对照组则采用利凡诺单独治疗,对两组患者的总产程和引产效果进行比较分析。结果:与对照组比较,观察组总产程明显缩短,差异有统计学意义(P<0.05);而且观察组成功的比率明显高于对照组,差异有统计学意义(P<0.05);两组成功引产的总比率比较,差异无统计学意义(P>0.05)。结论:利凡诺联合米非司酮与米索前列醇是一种终止中期妊娠有效且可靠的方法。
[关键词] 利凡诺;米非司酮;米索前列醇;中期妊娠
[中图分类号]R169.42 [文献标识码]B [文章编号]1673-7210(2010)05(a)-068-02
Clinical efficacy of Rivanol termination of the mid-term pregnancy with Mifepristone and Misoprostol
WANG Danying
(Guangxi Hechi City Jinchengjiang Area of Family Planning Guidance Station, Hechi 547000, China)
[Abstract] Objective: To investigate the clinical efficacy of Rivanol termination of the mid-term pregnancy with Mifepristone and Misoprostol. Methods: From June 2008 to September 2009 in our station, 118 cases of pregnant women to terminate pregnancy were selected, the patients were randomly divided into the observation group and the control group, 59 cases in each group. The observation group were treated with Rivanol, Mifepristone and Misoprostol combination therapy, the control group was used Rivanol alone, the total production process and induced abortion effects of patients in two groups were compared and analyzed. Results: Compared with the control group, the overall delivery process of the observation group was significantly shorter, the differences was statically significant (P<0.05). At the same time, compared with the control group, the success rate of the observation group was significantly higher, the differences was statically significant (P<0.05). The overall rate of successful induction of labor of two groups were compared, the difference was not statistically significant (P>0.05). Conclusion: Rivanol termination of the mid-term pregnancy with Mifepristone and Misoprostol is an effective and reliable method.
[Key words] Rivanol; Mifepristone; Misoprostol; Mid-term pregnancy
中期引产是指由于某种原因妊娠12～28周要求终止妊娠而采取的措施[1]。由于其妊娠月份大,胎盘和子宫之间附着较紧,胎儿和子宫也较大,因而比早期妊娠流产要困难,容易导致出血量多[2]。因此,2008年6月～2009年9月期间,我站将利凡诺与米非司酮和米索前列醇联合用于终止中期妊娠,效果显著,现将结果报道如下:
1 资料与方法
1.1 一般资料
选择2005年6月～2009年9月期间,我站收治的要求终止妊娠的118例孕12～28周的孕妇,年龄18～43岁,平均(28.43±12.43)岁。所有孕妇身体健康,无内科合并症,常规及妇科检查均在正常范围内。随机分为观察组和对照组,每组59例,两组患者年龄和孕周等一般资料比较,差异无统计学意义(P>0.05),具有可比性。
1.2 研究方法
对照组入院后次日按常规经羊膜腔内注射利凡诺100 mg引产。观察组入院后即口服米非司酮50 mg,12 h后重复1次,共100 mg,服药前后2 h内禁食。同时羊膜腔内注射利凡诺100 mg,24 h后阴道内置米索前列醇200 μg,每12小时重复1次,最多3次。产时出血多或有胎盘滞留或残留者立即行清宫术,其余则胎儿胎盘娩出后常规行清宫术。
1.3 评价治疗
对两组患者的总产程和引产效果进行比较分析。引产效果,①成功:用药后36 h内自然分娩;②有效:用药后36 h内人工助产分娩;③无效:用药后72 h未分娩。成功和有效均为引产成功,而无效则为引产失败。
1.4 统计学处理
数据采用SPSS 12.0软件进行统计学处理和分析,计量资料采用t 检验,计数资料采用χ2检验。P<0.05为差异有统计学意义。
2 结果
2.1 两组患者总产程的比较
与对照组比较,观察组总产程明显缩短,差异有统计学意义(P<0.05)。见表1。
表1两组患者总产程的比较(x±s)
与对照组比较,*P<0.05
2.2 两组患者引产效果的比较
与对照组比较,观察组成功的比率明显高于对照组,差异有统计学意义(P<0.05);两组成功引产的总比率比较,差异无统计学意义(P>0 ......
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