HCG日血清孕酮水平对IVF-ET结局的影响(1)
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[摘要] 目的:探讨体外受精-胚胎移植(IVF-ET)患者注射人绒毛膜促性腺激素(HCG)日血清孕酮(P)水平对IVF-ET妊娠结局的影响。方法:回顾性分析我中心2008～2009年经过IVF-ET治疗后行胚胎移植术的患者1 416个周期的临床资料。根据注射HCG日血清P水平,分为P<2 ng/ml(A组),2 ng/ml≤P<3 ng/ml(B组),P≥3 ng/ml(C组),比较各组患者年龄、不孕年限、内膜厚度、窦卵泡数、获卵数、胚胎数、优胚数、移植胚胎数、种植率和临床妊娠率。结果:各组患者年龄、不孕年限、内膜厚度、窦卵泡数、获卵数、胚胎数、优胚数、移植胚胎数均无显著性差异。A组种植率为27.81%、临床妊娠率为42.89%;B组种植率为22.36%、临床妊娠率为36.48%;C组种植率为15.96%、临床妊娠率为27.27%,各组比较有显著性差异。结论:IVF-ET中,注射HCG日血清P水平升高可引起临床妊娠率和种植率的下降。
[关键词] 体外受精-胚胎移植;孕酮;绒毛膜促性腺激素
[中图分类号] R169.4[文献标识码]A [文章编号]1673-7210(2010)06(a)-031-02
Effect of serum progesterone on the day of human chorionic gonadotrophin administration on clinical outcome in IVF-ET
FAN Li, WEI Jihong, KUANG Huan
(Reproductive Assisted Reproductive Center, Maternal and Child Health Hospital of Liuzhou City, Liuzhou 545001, China)
[Abstract] Objective: To evaluate the effect of serum progesterone on the day of human chorionic gonadotrophin administration on clinical outcome in IVF-ET. Methods: 1 416 cycles of infertile patients undergoing IVF-ET from January 2008 to December 2009 were reviewed. The cycles were divided into three groups according to serum progesterone levels on the day of HCG administra-tion: P<2 ng/ml (group A),2 ng/ml≤P<3 ng/ml (group B),P≥3 ng/ml (group C). Then compared their age, infertility duration, thick of endometrium, follicle numbers, the number of oocytes, embryos, ET embryos, implantation rate and pregnancy rate. Results: Their age, infertility duration, thick of endometrium, follicle numbers, the number of oocytes, embryos, ET embryos were no significant difference in all groups. Implantation rates were 27.81%, 22.36% and 15.96% respectively and pregnancy rates were 42.89%, 36.48% and 27.27%, the differences were statistically significant. Conclusion: Implantation rate and pregnancy rate significantly decrease when serum progesterone levels on the day of HCG administration increase.
[Key words] In vitro fertilization-embryo transfer; Progesterone; Human chorionic gonadotrophin
提高体外受精-胚胎移植患者的临床妊娠率是每一个辅助生殖医生的不懈追求,成功的关键在于获得高质量的卵子以及子宫内膜具有良好的容受性 ......
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