进展性前列腺癌患者VEGF含量测定及意义(1)
 |
| 第1页 |
参见附件(1285KB，2页)。
[摘要] 目的:测定前列腺癌(PCA)患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)和前列腺特异性抗原(PSA)含量,探讨其临床价值。方法:采用酶标记免疫吸附测定法(enzyme labeled immunosorbent assay,ELISA)测定45例PCA患者血清中VEGF和PSA水平,并以32例良性前列腺增生(BPH)作对照。结果:PCA组血清VEGF为(50.17±8.03) pg/ml,高于BPH组,差异有高度统计学意义(P<0.01);Ⅲ+Ⅳ期前列腺癌血清VEGF为(52.71±8.15) pg/ml,高于Ⅰ+Ⅱ期,差异有统计学意义(P<0.05);淋巴结转移患者血清VEGF为(49.46±7.26) pg/ml,高于未转移者,差异有统计学意义(P<0.05)。结论:血清VEGF与PCA的临床分期和浸润转移有一定的关系,其检测对PCA术前病情判断、疗效和预后评价有一定的临床意义。
[关键词] 前列腺癌;血管内皮生长因子;前列腺特异性抗原
[中图分类号] R737.25[文献标识码]A [文章编号]1673-7210(2010)06(b)-024-02
Level of serum vascular endothelial growth factor in patients with prostatic cancer
SHI Junqing1, ZHANG Xiaoxue2, SHI Feng3
(1.Shanxi Yuncheng City Health School, Yuncheng 044000, China; 2.Children's Hospital of Shanxi Province, Taiyuan 030001, China; 3.The Affiliated Hospital of Shanxi Yuncheng City Health School, Yuncheng 044000, China)
[Abstract] Objective: To detect the level of serum vascular endothelial growth factor (VEGF) in patients with prostatic cancer and to investigate its clinical value. Methods: Enzyme labeled immunosorbent assay (ELISA) was used to detect the level of serum VEGF and prostate specific antige (PSA) in 32 benign prostatic hyperplasia (BPH) cases of normal control subjects and 45 cases of patients with prostatic cancer. Results: The serum VEGF in all patients with prostatic cancer [(50.17±8.03) pg/ml] was higher than that of benign prostatic hyperplasia (P<0.01), the serum VEGF level in stageⅢ-Ⅳ[(52.71±8.15) pg/ml] was higher in comparison with stageⅠ-Ⅱ (P<0.05), the serum VEGF level with lymphatic metastasis (+) [(49.46±7.26) pg/ml] was higher than that with lymphatic metastasis (-) (P<0.05). Conclusion: The VEGF level is correlated with clinical stage, invasion and metastasis, it may be useful to preoperative evaluation, curative effect and prognosis.
[Key words] Prostatic cancer; Vascular endothelial growth factor; Prostate specific antigen
恶性肿瘤的进展最重要的特点是侵袭性生长和远处转移,肿瘤血管生成在肿瘤发展中起着重要的作用。血管内皮生长因子(vascular endothelial growth factor,VEGF)是目前发现的最重要的血管生长因子,参与了多种人类恶性肿瘤血管生长的调节[1]。本研究采用ELISA法测定前列腺癌(PCA)患者血清VEGF含量变化,探讨循环中VEGF与PCA临床分期、浸润转移的关系。
1 材料与方法
1.1 材料
山西医科大学第一附属医院及山西省运城市卫生学校附属医院2007年6月～2008年9月收治泌尿外科住院患者,PCA组45例,平均年龄67 ......
您现在查看是摘要介绍页，详见PDF附件(1285KB，2页)。